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대장암 경구 항암보조치료제 유에프티(UFT)의 독성에 관한 연구

Toxicity Evaluation of Oral Adjuvant Chemotherapeutic Drug UFT in the Colorectal Cancer

대한대장항문학회지 1998년 14권 2호 p.173 ~ 177
김진천 ( Kim Jin-Cheon ) - 울산대학교 의과대학 서울중앙병원 일반외과학교실

김창남 ( Kim Chang-Nam ) - 울산대학교 의과대학 외과학교실
김희철 ( Kim Hee-Cheol ) - 울산대학교 의과대학 외과학교실
유창식 ( Yu Chang-Sik ) - 울산대학교 의과대학 외과학교실
김병식 ( Kim Byung-Sik ) - 울산대학교 의과대학 외과학교실
이제환 ( Lee Je-Hwan ) - 울산대학교 의과대학 내과학교실
김우건 ( Kim Woo-Kun ) - 울산대학교 의과대학 서울중앙병원 내과학교실

Abstract


The addition of Uracil to Tegafur of 5-fluorouracil(5-FU) precursor(Tegafur and Uracil in a molar ratio of 1:4) is known to enhance the antineoplastic effect of 5-FU. This oral regimen also reduces side-effects attributed to 5-FU catabolism. The
toxicity of UFT was evaluated in 61 patients with colorectal cancer who underwent curative surgery. All patients had advanced cancer requiring adjuvant chemotherpy, but their age(over 70 years-old) or general condition precluded intravenous systemic chemotherpy. Oral UFT (400 mg of tegafur, 4 tablet/day) was administered in divided doses every 12 hour for mean duration of 6.2 months(range, 1∼13 months). The toxicity mainly disclosed hematological, gastrointestinal and dermatological complications. Leukopenia(20%), anemia (11%), anorexia(11%), nausea and vomiting(10%), abdominal pain(8%) and cutaneous toxicity including erythema or pruritus(7%). However, severity of toxicity seemed to be mild within grade 1 or 2 and most of them revealed self-limiting. They were relieved by symptomatic treatment or several months of rest. The regimen was completely interrupted in 3 patients(4.9%) due to prolonged leukocytopenia or derangement of liver function. There was no mortality from surgery or any drug-related toxicity during study period. Conclusively, oral UFT can be administered safely on an outpatient basis without lethal toxicity requiring hospitalization. It can be applicable especially in the risk groups need systemic adjuvant chemotherapy after surgery.

키워드

UFT;Toxicity;Colorectal cancer
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