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과산화수소용액으로 관장한 후 발생한 화학성대장염

A Case of Hydrogen Peroxide Enema Induced Chemical Colitis

대한대장항문학회지 1998년 14권 2호 p.317 ~ 320
이승철 ( Lee Sung-Cheorl ) - 건국대학교 의과대학 내과학교실

유종길 ( Yoo Jong-Kil ) - 건국대학교 의과대학 내과학교실
박형석 ( Park Hyung-Seok ) - 건국대학교 의과대학 내과학교실
이재동 ( Lee Jae-Dong ) - 건국대학교 의과대학 내과학교실
진춘조 ( Jin Chun-Jo ) - 건국대학교 의과대학 내과학교실
김보균 ( Kim Bo-Kyen ) - 건국대학교 의과대학 일반외과학교실
박웅채 ( Park Ung-Chae ) - 건국대학교 의과대학 외과학교실
박의우 ( Park Eui-U ) - 건국대학교 의과대학 병리학교실

Abstract


Hydrogen peroxide solution is commonly used for irrigating and cleaning wounds. When it is applied to tissues, catalase causes its rapid molecular degeneration with the release of oxygen bubbles. We present case report illustrating two hazards ; chemical colitis and oxygen embolus. A 29-year-old previously healthy woman presented to the bloody diarrhea and anal pain after hydrogen peroxide enema. In the colonoscopic examination, severe mucosal edema and ulceration with bleeding was noted from anus to sigmoid colon. With use of anal endosonography, multiple high level echo were noted in the internal and external anal sphincter of the upper anal canal. Microscopically, mononuclear cells were infiltrated in lamina propria and congestion. She had treatment with IV fluid, IV antibiotics and NPO. At 3rd hospital day, anal pain was disappeared. Bloody stool was disappeared next day. At 8th hospital day, mucosal edema and ulceration were disappeared on colonoscopic examination. Recovery was full and the patient was discharged at nine days after the episode.

키워드

Hydrogen peroxide;Chemical colitis;Oxygen bubble
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