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결직장암종에서의 면역조직학적 CEA 염색양상 및 PCNA발현율에 대한 연구

A Study on the Relationship between CEA Immunohistochemical Findings and Expression Rate of PCNA and Clinicopathologic Factors of Colorectal Cancers

대한대장항문학회지 1998년 14권 4호 p.725 ~ 733
홍관희 ( Hong Kwan-Hee ) - 인제대학교 의과대학 부산백병원 외과학교실

전병민 ( Jun Byung-Min ) - 인제대학교 부산백병원 일반외과학교실
김종익 ( Kim Jong-Ik ) - 인제대학교 부산백병원 일반외과학교실


Immunohistochemical study was performed for CEA staining patterns and PCNA indices. And the relationship between immunohistochemical findings and well-known clinical prognostic factors on the purpose of the clinical usefulness was evaluated. In forty seven cases of surgically removed colorectal carcinomas, the results were as follows; CEA staining patterns were apical (17 cases) and cytoplasmic (30 cases) type. Carcinomas with cyto plasmic pattern for CEA revealed more advanced Dukes’ stage and more undifferentiated type and higher incidence of lymph node metastasis and were correlated with increased serum CEA levels. But PCNA indices showed no correlation with the Dukes’ stage, histologic grade and CEA staining patterns. The cytoplasmic pattern of CEA immunohistochemistry may be a useful marker suggesting more aggressive biologic behavior of the colorectal carcinomas.


CEA (Carcinoembryonic antigen);PCNA (Proliferating cell nuclear antigen);Colorectal carcinoma
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