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치핵절제술후 합병증에 대한 베니톨(Venitol®)의 임상적 효과 무작위 할당, 위약대조시험

Clinical Effects of Venitol® on Complications after Hemorrhoidectomy Prospective Randomized and Placebo-controlled Trial

대한대장항문학회지 1998년 14권 4호 p.761 ~ 766
이흥우 ( Lee Heung-Woo ) - 성균관대학교 의과대학 삼성서울병원 외과학교실

이우용 ( Lee Woo-Yong ) - 성균관대학교 의과대학 삼성서울병원 외과학교실
전호경 ( Chun Ho-Kyung ) - 성균관대학교 의과대학 삼성서울병원 외과학교실


Fifty four patients who received closed hemorrhoidectomy were randomized into two parallel groups and treated with Venitol®(a micronized flavonoidic fraction containing diosmin 450 mg and hesperidin 50 mg) (group 1) or placebo (group 2). Venitol® was administered at the dosage of three toblets b.i.d. the first four days and two tablets b.i.d following three days. Postoperative analgesia and laxative prescription as well as hospital stay were same in two groups. Though there is no difference of symptoms at D1, improvement of symptoms of complications was greater in group 1 than in group 2 at D18. The clinical severity of postoperative spot-bleeding, pain and anal discharge diminished in both groups but to a greater extent in group 1 (P<0.005). There was no side-effects in using Venitol®. In summary, Venitol® is effective in reducing complications after hemorrhoidectomy.


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