잠시만 기다려 주세요. 로딩중입니다.

대장암과 Human Papillomavirus의 연관성

Association of Human Papillomavirus with Human Colorectal Cancer

대한대장항문학회지 2001년 17권 6호 p.332 ~ 336
민병욱 ( Min Byung-Wook ) - 고려대학교 의과대학 외과학교실

홍정훈 ( Hong Jeong-Hun ) - 고려대학교 의과대학 외과학교실
이경범 ( Lee Kyung-Bum ) - 고려대학교 의과대학 외과학교실
문홍영 ( Moon Hong-Young ) - 고려대학교 의과대학 외과학교실

Abstract


Purpose: The aim of this study is to confirm the association of human papillomavirus with colorectal cancer.

Methods: We studied 44 patients who were received operation for colorectal cancer from 1, Jan. 1997 to 31, Dec. at Korea University Guro Hospital. We used paraffinembedded tissue sections of colorectal adenocarcinomas and human cervical cell lines as a positive control. We also studied 10 cases of anal canal squamous cell carcinomas. The extracted DNA were analyzed by polymerase chain reaction and enzyme restriction method.

Results: Human papillomavirus DNA was not detected in all specimen of colorectal adenocarcinomas. But in 3 of 10 (30%) of anal canal squamous carcinomas, human papillomavirus DNA was detected. We identified this human papillomvirus DNA as type 16 by enzyme restriction technique.

Conclusions: Human papillomavirus usually associated with malignant transformation are present in anal canal squamous cell carcinomas. This study also showed same result. But this association was absent from adenocarcinoma of the colon and rectum.

키워드

대장암;항문관 편평상피세포암
Colorectal cancer;Human papillomavirus;Anal canal squamous carcinoma
원문 및 링크아웃 정보
  
등재저널 정보
KCI
KoreaMed
KAMS