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대장암에서 β-catenin 및 p53 단백의 발현양상과 종양의 병리학적 특성 간의 상호관계

Correlation of β-catenin and p53 Protein Expression with Clinico-pathologic Characteristics of Colorectal Cancer

대한대장항문학회지 2002년 18권 5호 p.311 ~ 316
문길민 ( Moon Kil-Min ) - 인제대학교 의과대학 일산백병원 외과학교실

박영진 ( Park Young-Jin ) - 인제대학교 의과대학 일산백병원 외과학교실
김한성 ( Kim Han-Seong ) - 인제대학교 의과대학 해부병리학교실
박성혜 ( Park Seong-Hye ) - 인제대학교 일산백병원 해부병리과
김지일 ( Kim Ji-Il ) - 인제대학교 의과대학 일산백병원 외과학교실
김기홍 ( Kim Ki-Hong ) - 인제대학교 의과대학 일산백병원 외과학교실
송병주 ( Song Byung-Joo ) - 인제대학교 의과대학 일산백병원 외과학교실
이명수 ( Lee Myung-Soo ) - 인제대학교 의과대학 일산백병원 외과학교실
김철남 ( Kim Chul-Nam ) - 인제대학교 의과대학 일산백병원 외과학교실
장석효 ( Chang Surk-Hyo ) - 인제대학교 의과대학 일산백병원 외과학교실

Abstract


Purpose: Both the β-catenin and p53 play a crucial role in the process of colon carcinogenesis. The expression of β-catenin and/or p53 has been reported to be associated with pathologic features of tumor and prognosis of patients. In
addition, several recent studies have suggested a close biological association between p53 expression and nuclear β-catenin level. We analyzed the pathologic variables and p53 expression according to the intra-nuclear β-catenin expression in colon cancer to make such assumptions more clear since they are still controversial issues.

Methods: The expressions of β-catenin, p53 and Ki-67 protein in colon cancer were determined by immunohistochemical staining. The relationship between these protein expressions and tumor characteristics was statistically analyzed.

Results: The intra-nuclear β-catenin accumulation was not associated with any of the pathological variables including lymph node metastasis and tumor differentiation, but it was correlated with higher level of Ki-67 proliferation index
(P=0.006) and negative staining of p53 (P =0.015). Positive p53 staining was significantly associated with lymph node metastasis (P=0.006), lymphatic invasion (P=0.03) and venous invasion (P=0.02).

Conclusion: These results support the suggestion that intra-nuclear accumulation of β-catenin may regulate the p53 activity in colorectal cancer. In addition, positive staining of p53 may be used as a valuable prognostic indicator since
it was strongly associated with lymph node metastasis, lymphatic and venous invasion.

키워드

대장암;림프절 전이;분화
Colorectal cancer;β-catenin;p53;Lymph node metastasis;Differentiation
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