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인접장기에 유착이 있는 T4 대장암 환자에 대한 임상적 고찰

Clinical Analysis of T4 Colorectal Cancer with Adhesion to Adjacent Organs

대한대장항문학회지 2003년 19권 5호 p.290 ~ 298
조문형 ( Cho Moon-Hyung ) - 전남대학교 의과대학 외과학교실 위장관외과

주재균 ( Ju Jae-Kyun ) - 전남대학교 의과대학 외과학교실 위장관외과
류성엽 ( Ryu Sung-Yub ) - 전남대학교 의과대학 외과학교실 위장관외과
김형록 ( Kim Hyeong-Rok ) - 전남대학교 의과대학 외과학교실 위장관외과
김동의 ( Kim Dong-YI ) - 전남대학교 의과대학 외과학교실 위장관외과
김영진 ( Kim Young-Jin ) - 전남대학교 의과대학 외과학교실 위장관외과

Abstract


Purpose: A colorectal cancer (CRC) is defined as T4 when the tumor directly invades other organs or structures and/or perforates the visceral peritoneum. The purpose of this study was to evaluate the results of a surgical approach and to determine the significant prognostic factors for tumor respectability and survival in patients with advanced T4 CRC.

Methods: A total of 61 patients with T4 CRC with adjacent organ adhesion, who received multivisceral resections at Chonnam University Hospital, Korea, between Jan. 1990 and Dec. 2001, were analyzed retrospectively.

Results: Cancer invasion to contiguous organs was present in 51 (83.6%) of the 61 patients who received a multivisceral resection and was absent in 10 (16.4%). Postoperative rates of complications and death were 22.9% and 4.9%, respectively, in the 61 patients. Lymph-node (LN) metastases were presented in 25 patients (41.0%). The 5-year survival rate (5 YSR) was 22.2% in patients with LN metastases, but was significantly higher (66.7%) in patients without LN metastases. The 5 YSRs for the 61 patients according to the AJCC cancer stage (TNM classification) were as follows: stage II (66.7%), stage III (46.4%), and stage IV (0%).

Conclusion: T4 CRC without distant metastases requires multivisceral en-bloc resection of any organ or structure to which the primary tumor is adhered. The presence of LN metastases at the time of surgery is one of the significant factors with a poor prognosis in T4 CRC.

키워드

결장직장종양;림프절;종양전이
Colorectal neoplasms;Lymph nodes;Neoplasm metastasis
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