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결장 직장암 환자에서 근치적 절제술 후 혈청 CEA치의 변화에 대한 임상적 의의

Clinical Value of the Change in the Serum Carcinoembryonic Antigen (CEA) Level after Curative Surgery in Colorectal Cancer

대한대장항문학회지 2003년 19권 6호 p.372 ~ 378
김영훈 ( Kim Young-Hoon ) - 인제대학교 상계백병원 외과학교실

배병노 ( Bae Byung-Noe ) - 인제대학교 의과대학 상계백병원 외과학교실
김기환 ( Kim Ki-Whan ) - 인제대학교 의과대학 상계백병원 외과학교실
한세환 ( Han Se-Hwan ) - 인제대학교 의과대학 상계백병원 외과학교실
김홍주 ( Kim Hong-Joo ) - 인제대학교 의과대학 상계백병원 외과학교실
김영덕 ( Kim Young-Duck ) - 인제대학교 의과대학 상계백병원 외과학교실
김홍용 ( Kim Hong-Yong ) - 인제대학교 의과대학 상계백병원 외과학교실

Abstract


Purpose: This retrospective study was designed to evaluate the clinical value of changes in the serum carcinoembryonic antigen (CEA) level after curative surgery in colorectal cancer patients.

Methods: The clinical value of preoperative serum CEA and dCEA (postoperative 7-day CEA/preoperative CEA) in 115 patients with colorectal cancer, who underwent curative surgery at our Department of General Surgery from 1994 to 1997, was investigated.

Results: The preoperative CEA level was significantly associated with histologic differentiation (P=0.035) and reccurence (P=0.044), but not gender, tumor size, lymph node metastases, Duke´s stage, and vascular invasion. dCEA was significantly associated with lymph-node metastases (P=0.017), histologic differentiation (P=0.024), Duke´s stage (P=0.021), recurrence (P=0.008), and survival rate (P=0.0379). Especially, in the abnormal preoperative CEA level (>5 ng/mL) group, if dCEA was more than 0.5, these patients had a very poor prognosis (P=0.0003).

Conclusions: dCEA was associated with more clinicopathologic prognostic factors than preoperative CEA, especially with survival rate. Therefore, we expect dCEA to be a more useful tool for predicting patient outcome. J Korean Soc Coloproctol 2003;19:372-378

키워드

암태아성항원;결장직장종양;생물학적종양표지자
Carcinoembryonic antigen/blood;Colorectal neoplasms;Tumor markers;Biological
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