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대장암에서 No Touch Isolation 술식이 종양전이 방지에 미치는 영향에 관한 CEA 연구

CEA Study on the Effect of the No-touch Isolation Technique for Preventing Tumor Metastasis in Patients with Colorectal Cancer

대한대장항문학회지 2004년 20권 2호 p.105 ~ 111
배옥석 ( Bae Ok-Suk ) - 계명대학교 의과대학 외과학교실

이태순 ( Lee Tae-Soon ) - 계명대학교 의과대학 외과학교실
박성대 ( Park Sung-Dae ) - 계명대학교 의과대학 외과학교실
박종욱 ( Park Jong-Wook ) - 계명대학교 의과대학 면역학교실
전동석 ( Jeon Dong-Suk ) - 계명대학교 의과대학 병리학교실

Abstract


Purpose: Although the ‘No-touch’ isolation technique was introduced by Turnbull et al. in 1967, the controversy over whether or not it reduces the risk of metastasis during surgery exists even today. The aim of this study was to evaluate the effect of the ‘No-touch’ isolation technique in primary colorectal cancer surgery.

Methods: The evaluation was done by comparing the levels of CEA and CEA m-RNA expression from the same draining vein before and after tumor mobilization. Blood samples from 25 patients with primary colorectal cancer were collected for analysis. At the time of surgery, the main draining vein from the tumor was isolated and ligated at the proximal end. The 1st blood samples were collected just prior to tumor mobilization, and the 2nd samples right after. Both samples were analyzed for serum CEA level and CEA mRNA expression by using reverse transcriptase polymerase chain reaction (RT-PCR).

Results: The mean CEA value from draining veins after tumor mobilization (8.08±8.98 ng/ml) was significantly higher than it was before mobilization (4.17±4.98 ng/ml). CEA mRNA was detected in 16% (4/25) of the blood specimens post-mobilization, whereas it was detected in only 4% (1/25) of the pre-mobilization samples.

Conclusions: The results suggest the validity of using the ‘No-touch’ isolation technique to reduce the risk of metastasis into the draining vein during mobilization. J Korean Soc Coloproctol 2004;20:105-111

키워드

암태아성항원;No-touch isolation technique;대장암
Carcinoembryonic antigen;No-touch isolation technique;Colorectal neoplasm
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