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결장직장 종양과 선종에서의 c-met 단백 발현과 임상, 병리학적 인자와의 상관관계

c-Met Expression in Colorectal Carcinoma and Adenomas: Correlation with Clinicopathologic Parameters

대한대장항문학회지 2004년 20권 4호 p.205 ~ 210
김진 ( Kim Jin ) - 고려대학교 의과대학 외과학교실

김정윤 ( Kim Chung-Yun ) - 고려대학교 의과대학 외과학교실
이원진 ( Lee Won-Jin ) - 고려대학교 의과대학 외과학교실
조성진 ( Cho Seong-Jin ) - 한림대학교 의과대학 해부병리학교실
민병욱 ( Min Byung-Wook ) - 고려대학교 의과대학 외과학교실
엄준원 ( Um Jun-Won ) - 고려대학교 의과대학 외과학교실
조민영 ( Cho Min-Young ) - 고려대학교 의과대학 외과학교실
서성옥 ( Seo Seong-Ok ) - 고려대학교 의과대학 외과학교실
문홍영 ( Moon Hong-Young ) - 고려대학교 의과대학 외과학교실
황정웅 ( Whang Jeong-Woong ) - 고려대학교 의과대학 외과학교실


Purpose: Hepatocyte growth factor (HGF) stimulates proliferation, migration, and morphogenesis of epithelial cells by specifically binding to its receptor c-met. Abnomalities of the c-met oncogene have been studied in cancers of many organs including thyroid, lung, pancreas, and stomach. However, little is known about the clinical significance of c-met oncogene abnormalities in colorectal carcinomas. In this study, we investigated over- expression of the c-met protein in colorectal adenomas and adenocarcinomas, and analyzed the clinicopathologic significance of this over-expression.

Methods: Expression of the c-met protein localized in colorectal adenoma and adenocarcinoma tissues was analyzed by using immunohistochemistry. The results were compared with clinicopathologic parameters to find clinical correlation.

Results: c-met protein was detected in 42.5% (17/40) of colorectal cancers and in 10.0% (4/40) of colorectal adenomas (P= 0.001). In colorectal cancer, the proportion of expression of c-met protein was 0% (0/40) in stage I, 47.6% (10/40) in stage II, 53.8% (7/40) in stage III and, 0% (0/40) in stage IV. c-met protein expression was 18.8% (3/40) in tumors with invasion into the muscularis propria (MP), and 58.3% (14/40) in tumors with invasion beyond the MP. The depth of tumor invasion was a statistically significant factor (P=0.022) for c-met expression.

Conclusions: The c-met protein expression was related to the depth of invasion of colorectal cancer and showed a significant difference in its rate of expression between adenoma and adenocarcinomas. J Korean Soc Coloproctol 2004;20:205-210


c-met 단백;결장직장 종양;결장직장 선종
Proto-oncogene protein c-met;Colorectal neoplasms;Adenoma
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