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간전이를 동반한 대장암 환자에서 원발 종양 및 간전이 종양의 베타-카테닌 발현

Expression of β-catenin in Colorectal Cancer with Liver Metastasis

대한대장항문학회지 2004년 20권 6호 p.391 ~ 398
한상아 ( Han Sang-Ah ) - 성균관대학교 의과대학 삼성서울병원 외과학교실

박치민 ( Park Chi-Min ) - 성균관대학교 의과대학 삼성서울병원 외과학교실
강신재 ( Kang Shin-Jea ) - 성균관대학교 의과대학 삼성서울병원 외과학교실
송상용 ( Song Sang-Yong ) - 성균관대학교 의과대학 삼성서울병원 병리학교실
김상희 ( Kim Sang-Hee ) - 삼성생명과학연구소
손대순 ( Son Dae-Soon ) - 삼성생명과학연구소
윤성현 ( Yun Seong-Hyeon ) - 성균관대학교 의과대학 삼성서울병원 외과학교실
이우용 ( Lee Woo-Yong ) - 성균관대학교 의과대학 삼성서울병원 외과학교실
전호경 ( Chun Ho-Kyung ) - 성균관대학교 의과대학 삼성서울병원 외과학교실

Abstract


Purpose: Decreased expression of β-catenin has been known to be associated with tumor metastasis. However, the clinical relationship between the degree of expression and the prognosis in colorectal cancer (CRC) remains unclear. In this study, we evaluated the prognostic value of β-catenin expression in CRC patients with liver metastasis.

Methods: Paraffin embedded blocks were obtained from 70 patients who underwent potentially curative resection for CRC with liver metastasis. Samples from normal colon mucosa, primary CRC and metastatic liver lesion were prepared in tissue microarrays and were stained by immunohistochemistry with monoclonal antibody against β- catenin. The membranous β-catenin expression was assessed and the β-catenin expression difference between primary CRC and metastatic liver lesion was analysed in relation to overall survival as well as disease free survival rates.

Results: In β-catenin expression, preserved expression (score >6) was observed in 42.0%, and 21.9% of primary CRC tumor samples and tumor samples from metastatic liver lesion respectively. The degree of β-catenin expression in metastatic liver lesion was significantly lower than that in primary CRC (P=0.022).According to the difference of β-catenin expression score between primary CRC and liver metastasis, patients were classified as group ´A´ and ´B´. Group ´A´ was defined as patients showing remarkably decreased expression of β-catenin in metastatic liver lesion in that the difference of the score was three or more. Group ´B´ was defined as patients showing maintained or increased β-catenin expression in metastatic liver lesion in comparison to primary CRC, in that the difference of β-catenin expression score was less than three. Overall survival rate and disease free survival rate were significantly better in group ´B´ than group ´A´ (P=0.02, P=0.002).

Conclusions: Decreased expression of β-catenin in metastatic liver lesion may be a poor prognostic marker in colorectal cancers with liver metastasis. A further large-scaled investigation is necessary to define the role of β-catenin in CRC. J Korean Soc Coloproctol 2004;20:391-398

키워드

베타 카테닌;대장 직장암;간전이;Tissue 마이크로어레이;면역조직화학염색
Beta-catenin;Colorectal neoplasm;Metastatic liver lesion;Tissue microarray;Immunohistochemistry
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