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대장암에서 EGFR 발현의 의의

The Significances of EGFR Overexpression in Colorectal Cancer

대한대장항문학회지 2005년 21권 1호 p.36 ~ 41
김현아 ( Kim Hyun-Ah ) - 이화여자대학교 의과대학 외과학교실

이령아 ( Lee Ryung-Ah ) - 이화여자대학교 의과대학 외과학교실
황대용 ( Hwang Dae-Yong ) - 한국원자력의학원 원자력병원 외과
박선후 ( Park Sun-Hoo ) - 원자력병원 해부병리과

Abstract


Purpose: Epidermal growth factor receptor (EGFR) is a transmembrane cell surface receptor which has tyrosine kinase activity stimulated upon EGF binding. EGFR was found to be up-regulated in various malignancies. Recently, chimeric monoclonal antibody (C225) to EGFR is under investigation as a targeted therapeutic agent for advanced colorectal cancer. Along with this advance, identification of EGFR expression in colorectal cancer became more important.

Methods: To investigate the expression of EGFR in colorectal cancer, we carried out the immunohistochemical staining in surgical specimen of 46 consecutive enrolled colorectal cancer patients of Korea Cancer Center Hospital from August, 1998 to June, 1999. The stained slides were read by pathologist and scored as negative or positive. These results were analyzed according to clinical parameters.

Results: Average age was 55 years old (32∼73 yr) and sex ratio was 1.56:1. The expression rate of EGFR in colorectal cancer was 56.5% (26/46 cases). EGFR expression was not correlated with age, sex, Tie-1, Tie-2 expression, TNM stage, lymphatic invasion, presence of distant metastasis, serum VEGF level. We could not find out staitistical difference of survival according to EGFR expression.

Conclusions: EGFR overexpression was well characterized by immunochemical staining method, which could be applied easily as a basic pathologic step to decide additional therapy after resection for advanced colorectal cancer.

키워드

대장암;면역조직화학 염색법
EGFR; Colorectal cancer; Immunohistochemical staining;EGFR
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