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대장암에서 Insulin-like Growth Factor Binding Proteins (IGFBPs)의 발현

Expression of the Insulin-like Growth Factor Binding Proteins (IGFBPs) in Colon Cancer

대한대장항문학회지 2008년 24권 3호 p.192 ~ 200
김찬동 ( Kim Chan-Dong ) - 이화여자대학교 의과대학 외과학교실

이령아 ( Lee Ryung-Ah ) - 이화여자대학교 의과대학 외과학교실
강보영 ( Kang Bo-Young ) - 이화여자대학교 의과대학 의과학연구소
김광호 ( Kim Kwang-Ho ) - 이화여자대학교 의과대학 외과학교실
이정은 ( Lee Jung-Eun ) - 이화여자대학교 의과대학 외과학교실

Abstract


Purpose: The purpose of this study was to demonstrate the hypothesis that tussue IGFBP-2,-3, and -4 levels would differ between colon cancer tissue and adjacent normal tissue and to determine whether these factors could affect the clinicopathologic characteristics such as age, tumor stage, differentiation, serosal invasion, and CEA in patients with colon cancer.

Methods: This study group consisted of 102 patients with colorectal cancer who under went operations between January 2004 and December 2006. Postoperative colon cancer specimens and adjacent normal colon tissues were obtained immediately. Histopathologic examinations were made by on pathologist for each specimen. The gene expressions of IGFBP-2,-3,-4 in cancer and normal tissues were measured using a reverse transcriptase-polymerase chain reaction (RT-PCR). In additional, the various clinicopathologic factors were evaluated for both tissues by comparing the IGFBP-2, -3, -4 expression densities.

Results: No significant difference was found in the expression of IGFBP-3, -4 between colon cancer and normal colon tissues. A statistically significant expression of IGFBP-2 was detected in the cancer specimens compared with the normal colon tissues. IGFBP-3 was significantly associated with pathologic N stage.

Conclusions: This is a rare report comparing colon cancer with normal colon tissue for IGFBP expression by means of a systemical evaluation of colon cancer patients. Our data suggest that IGFBP-2 may be intimately associated with malignant phenotypes, and may confer some growth advantage on tumor cells, which means that IGFBP-2 shows a high sensitivity for colorectal cancer. Interestingly, IGFBP-3 was strongly associated with the pathologic N stage. We think further studies are needed to understand this phenomenon. J Korean Soc Coloproctol 2008;24:192-200

키워드

IGFBPs;역전사 중합효소 연쇄반응;대장암
Insulin-like growth factor binding proteins (IGFBPs);RT-PCR;Colorectal cancer
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