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대장암에서의 Hypoxia Inducible Factor-1α (HIF-1α) 및 Vascular Endothelial Growth Factor (VEGF): 예후 및 종양표지자로서의 가능성

Expression of Hypoxia-inducible Factor- 1α and Vascular Endothelial Growth Factor in Colon Cancer: Relationship to the Prognosis and Tumor Markers

대한대장항문학회지 2008년 24권 5호 p.337 ~ 344
최윤영 ( Choi Yoon-Young ) - 순천향대학교 의과대학 외과학교실

조현득 ( Cho Hyun-Deuk ) - 순천향대학교 의과대학 병리학교실
박동국 ( Park Dong-Guk ) - 단국대학교 의과대학 외과학교실
김성용 ( Kim Sung-Yong ) - 순천향대학교 의과대학 외과학교실
이문수 ( Lee Moon-Soo ) - 순천향대학교 의과대학 외과학교실
김창호 ( Kim Chang-Ho ) - 순천향대학교 의과대학 외과학교실
조무식 ( Cho Moo-Sik ) - 순천향대학교 의과대학 외과학교실
백무준 ( Baek Moo-Jun ) - 순천향대학교 의과대학 외과학교실


Purpose: Angiogenesis is one of the key steps in solid tumor growth and metastasis. We investigated the prognostic significance of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α
) expressions as markers of angiogenesis in colon cancer.

Methods: We retrospectively reviewed the medical records of 78 patients with colon or rectal cancer who underwent a surgical resection at Soonchunhyang University Hospital from January 2000 to December 2001, and we evaluated the expression of VEGF and HIF-1α in archival tumor tissues by using immunohistochemistry. We recorded the clinical and the pathological characteristics of the patients and analyzed their survival outcomes.

Results: Thirty-four (34) patients were male, and the mean age of all the patients was 66.7 years. HIF-1α
and VEGF were positive in 56% (44 patients) and 53% (42 patients) of the tumors, respectively. HIF-1? expression was significantly associated with several pathological parameters, such as TNM stage (P=0.001), lymph node metastasis (P=0.001). HIF-1α expression was also associated with VEGF expression (P=0.032). The survival of patients with HIF-1α
expression was worse than that of patients with no HIF-1α expression (P=0.036). However, VEGF expression was not associated with other pathological characteristics.

Conclusions: We suggest that, in cases of colorectal cancer, HIF-1α expression may be associated with expression of VEGF, progression of tumors, and poor prognosis.


Colorectal cancer;HIF-1α;VEGF;Angiogenesis
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