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결장직장암 환자에서 수술 전 적혈구 침강 속도에 따른 예후 분석

Prognostic Value of Erythrocyte Sedimentation Rate in Patients with Colorectal Cancer

대한대장항문학회지 2008년 24권 5호 p.351 ~ 356
김영기 ( Kin Young-Ki ) - 인제대학교 의과대학 서울백병원 외과학교실

홍성우 ( Hong Seong-Wo ) - 인제대학교 의과대학 서울백병원 외과학교실
천정우 ( Chun Jung-Woo ) - 서울정형외과
장여구 ( Chang Yeo-Goo ) - 인제대학교 의과대학 서울백병원 외과학교실
백인욱 ( Paik In-Wook ) - 인제대학교 의과대학 서울백병원 외과학교실
이혁상 ( Lee Hyuck-Sang ) - 인제대학교 의과대학 서울백병원 외과학교실

Abstract


Purpose: Prognostic indicators are used increasingly in clinical trials and to guide surveillance for patients with colorectal cancer (CRC). The significance of a preoperative, elevated erythrocyte sedimentation rate (ESR) as a predictive indicator for malignancy and for prognosis in colorectal cancer has not been elucidated. Hence, the current study was conducted to evaluate the ESR as a prognostic indicator in patients with CRC.

Methods: This study enrolled 232 patients who underwent surgery in our hospital between 1997 and 2004. ESR with clinicopathologic features and overall survival were evaluated retrospectively.

Results: The ESRs of 139 patients were elevated, and those of 93 patients were normal. Elevated ESR was associated with the male gender, decreased hemoglobin, increased platelet count, high preoperative CEA, high preoperative CA19-9, tumor size (≥5 cm), T stage, and TNM stage. Patients with elevated ESR had poorer survival (P=0.001), but a multivariate analysis did not reveal an elevated ESR as an independent factor for prognosis.

Conclusions: Preoperative elevation of ESR in patients with CRC suggests the presence of a tumor with aggressive behavior and a poor outcome. J Korean Soc Coloproctol 2008;24:351-356

키워드

적혈구 침강 속도;결장직장암;예후;생존율
Erythrocyte sedimentation rate;Colorectal cancer;Prognosis;Survival
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