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Stage III 진행성 대장암에서 α-catenin과 E-cadherin의 발현 양상과 전이인자로서의 임상적 유용성

Expression of Alpha-catenin/E-cadherin and Clinical Significance of Metastatic Factors in Stage III Advanced Colon Cancer

대한대장항문학회지 2009년 25권 5호 p.334 ~ 339
채승훈 ( Chae Seung-Hun ) - 서울적십자병원 일반외과

김재만 ( Kim Jae-Man ) - 서울적십자병원 일반외과
김한선 ( Kim Han-Sun ) - 서울적십자병원 일반외과
이상희 ( Lee Sang-Hee ) - 서울적십자병원 일반외과
이미경 ( Lee Mi-Keung ) - 서울적십자병원 일반외과
정완조 ( Jung Wan-Jo ) - 서울적십자병원 일반외과
이호준 ( Lee Ho-Jun ) - 서울적십자병원 일반외과

Abstract


Purpose: Among the cell adhesion molecules, α-catenin and E-cadherin play an important part in maintaining normal cell structure. The change in expression of cell adhesion molecules affects the invasion and metastasis of a tumor and the prognosis for patients. In this study, we evaluated the relationship between the expression of cell adhesion molecules and the histopathologic characteristics of stage III colon cancer.

Methods: The relationship between the immunohistochemical expression of cell adhesion molecules and tumor progression were statistically analyzed in 40 patients with stage III colon cancer.

Results: There were no statistically significant correlations between loss of membranous α-catenin and E-cadherin expressions and such variables as histologic differentiation and lymph node disease based on the criteria of the American Joint Committee on Cancer (AJCC). A significant correlation, however, existed between depth of mural invasion and loss of expressions of both α-catenin and E-cadherin (P=0.001 and P=0.002, respectively). Expressions of both α-catenin and E-cadherin were also significantly decreased in patients showing liver metastases during follow-up (P=0.019 and P=0.015, respectively).

Conclusion: Immunohistochemical analyses of α-catenin and E-cadherin expressions may be available as predictors for distant metastasis, especially in stage III colon cancer. Such analyses may also help to identify appropriate therapeutic strategies and the need for intensive follow-up in patients with stage III colon cancer.

키워드

이카데린;알파카테닌;3기 결장암
E-cadherin; α-catenin;Stage III Colon Cancer
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