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Nude Mice에 이종이식한 대장암에서의 Inositol Hexaphosphate의 항종양효과의 초기실험

Anticancer Effects of IP6 in a Human Colon Carcinoma Cell Line in Nude Mice Xenografts

대한대장항문학회지 2010년 26권 2호 p.93 ~ 97
김찬동 ( Kim Chan-Dong ) - 이화여자대학교 의과대학 외과학교실

이령아 ( Lee Ryung-Ah ) - 이화여자대학교 의과대학 외과학교실
김광호 ( Kim Kwang-Ho ) - 이화여자대학교 의과대학 외과학교실
이정은 ( Lee Jung-Eun ) - 이화여자대학교 의과대학 외과학교실

Abstract


Purpose: Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that has been shown to suppress the growth of epithelial cancer. Because IP6 is a dietary phytochemical present in cereals, soy, legumens, and fiber-rich foods, we evaluated the efficacy of IP6 against colon cancer formation.

Methods: HT-29 cells were injected into nude mice. The animals were fed a normal diet (group 1), a low IP6 diet (group 2), and a high IP6 diet (group 3) for 4 wk. Body weight, tumor volume, tumor growth rate, growth inhibition rate, and therapeutic ratio were monitored after injection of HT-29 cells.

Results: HT-29-cell human-colon-carcinoma xenograft mice treated with IP6 showed a significant reduction in tumor growth rate, irrespective of the IP6 dose compared to normal diet group. Compared with the control group, group 3 showed a significant reduction (45%) in tumor volume. In the therapeutic ratio gain profiles, IP6 diet groups showed a significant alteration of therapeutic ratio when compared with the normal diet group (0% vs. 11%, P=0.014). In the body weight gain profiles, group 3 showed a significant reduction of body weight compared with the other two groups (20.25 g vs. 21.6 g, 21.7 g, P=0.009). Groups 1 and 2 showed similar changes in body weight. Tumor xenografts from IP6-fed mice showed significantly decreased cancer formation and growth, but increased toxicity was noted for high doses of IP6.

Conclusion: These results indicate that in the future, IP6 could be an effective chemopreventive or chemotherapeutic agent for use in the treatment of colon cancer.

키워드

피틴산;이종이식;대장암
CInositol hexaphosphate (IP6);Xenografts;Colon cancer
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