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Risk Factors for the Development of Clostridium difficile-associated Colitis after Colorectal Cancer Surgery

대한대장항문학회지 2010년 26권 5호 p.329 ~ 333
염창호 ( Yeom Chang-Ho ) - 계명대학교 의과대학 외과학교실

조민미 ( Cho Min-Mi ) - 계명대학교 의과대학 외과학교실
백성규 ( Baek Seong-Kyu ) - 계명대학교 의과대학 외과학교실
배옥석 ( Bae Ok-Suk ) - 계명대학교 의과대학 외과학교실

Abstract


Purpose Clostridium difficile (C. difficile)-associated colitis, a known complication of colon and rectal surgery, can increase perioperative morbidity and mortality, leading to increased hospital stay and costs. Several contributing factors, including advanced age, mechanical bowel preparation, and antibiotics, have been implicated in this condition. The purpose of this study was to determine the clinical features of and factors responsible for C. difficile-associated colitis after colorectal cancer surgery.

Methods The medical records of patients who had undergone elective resection for colorectal cancer from January 2008 to April 2010 were reviewed. Cases that involved procedures such as transanal excision, stoma creation, or emergency operation were excluded from the analysis.

Results Resection with primary anastomosis was performed in 219 patients with colorectal cancer. The rate of postoperative C. difficile-associated colitis was 6.8% in the entire study population. Preoperative metallic stent insertion (P = 0.017) and aged sixty and older (≥ 60, P = 0.025) were identified as risk factors for postoperative C. difficile-associated colitis. There were no significant differences in variables such as preoperative oral non-absorbable antibiotics, site of operation, operation procedure, and duration of prophylactic antibiotics.

Conclusion Among the potential causative factors of postoperative C. difficile-associated colitis, preoperative metallic stent insertion and aged sixty and older were identified as risk factors on the basis of our data. Strategies to prevent C. difficile infection should be carried out in patients who have undergone preoperative insertion of a metallic stent and are aged sixty and older years.

키워드

Clostridium difficile; Colitis; Colorectal cancer
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