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Relation of the Expression of Cyclooxygenase-2 in Colorectal Adenomas and Adenocarcinomas to Angiogenesis and Prognosis

대한대장항문학회지 2010년 26권 5호 p.339 ~ 346
한윤대 ( Han Yoon-Dae ) - 연세대학교 의과대학 외과학교실

 ( Hong Young-Ki ) - 국민건강보험공단 일산병원 외과학교실
강중구 ( Kang Jung-Gu ) - 국민건강보험공단 일산병원 외과학교실
최윤정 ( Choi Yoon-Jung ) - 국민건강보험공단 일산병원 병리과
박찬흔 ( Park Chan-Heun ) - 한림대학교 의과대학 강동성심병원 외과학교실


Purpose Recent studies have shown that cyclooxygenase (COX)-2 may be involved in tumor growth, invasion and apoptosis in various carcinomas. Vascular endothelial growth factor (VEGF) has a potent angiogenic activity, and COX-2 promotes angiogenesis by modulating angiogenic factors, including VEGF. Endothelial growth factor receptor (EGFR) is considered as a factor of cell growth, maturation and cell death. The current study was designed to investigate the possible roles of COX-2 in colorectal tumor progression and angiogenesis.

Methods Fifty colorectal adenomas and forty adenocarcinomas were investigated by using immunohistochemical staining for COX-2, VEGF and EGFR. The correlations of COX-2, VEGF and EGFR with the grade of dysplasia, the size of the adenoma, and various clinicopathologic factors were studied.

Results The expressions of COX-2, VEGF and EGFR were each significantly correlated with carcinomatous transformation, and the expressions of COX-2 and VEGF were significantly correlated. COX-2 and EGFR showed correlations with adenomas rather than adenocarcinomas. However, no correlations of COX-2, VEGF and EGFR expression to other clinicopathologic factors, except tumor size in EGFR expression, were detected.

Conclusion These results suggest that COX-2 may play an important role in carcinogenesis through interaction with VEGF and EGFR in human colorectal cancer.


Cyclooxygenase 2; Vascular endothelial growth factor; Endothelial growth factor receptor; Colorectal carcinoma; Adenocarcinoma
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