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Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report

대한대장항문학회지 2011년 27권 3호 p.157 ~ 161
 ( Kim Yo-Na ) - Chonbuk National University Medical School Department of Pathology

 ( Park Ho-Sung ) - Chonbuk National University Medical School Department of Pathology
 ( Jang Kyu-Yun ) - Chonbuk National University Medical School Department of Pathology
문우성 ( Moon Woo-Sung ) - Chonbuk National University Medical School Department of Pathology
 ( Lee Dong-Geun ) - Chonbuk National University Medical School Department of Pathology
 ( Lee Ho ) - Chonbuk National University Medical School Department of Forensic Medicine
 ( Lee Min-Ro ) - Chonbuk National University Medical School Department of Surgery
김경렬 ( Kim Kyung-Ryoul ) - National Institute of Science Investigation Department of Forensic Medicine

Abstract


Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 × 5.1 cm ulcerative fungating lesion, and the other was a 2.8 × 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.

키워드

Colon neoplasms; Carcinoma; Neuroendocrine; Adenocarcinoma
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