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Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1?

대한대장항문학회지 2011년 27권 5호 p.237 ~ 240
임청호 ( Lim Cheong-Ho ) - 양병원 대장항문외과

 ( Kang Wook-Ho ) - 양병원 대장항문외과
 ( Shin Hyeon-Keun ) - 양병원 대장항문외과
정승규 ( Jeong Seung-Kyu ) - 양병원 대장항문외과
양형규 ( Yang Hyung-Kyu ) - 양병원 대장항문외과


Purpose: Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is produced by endothelial activation, in patients with chronic anal fissure and to infer the relationship between ET-1 and anal fissure chronicity.

Methods: The study groups are divided into three different groups with 30 subjects each. Group 1 is comprised of healthy volunteers, group 2 of chronic anal fissure patients, and Group 3 of patients with higher than 3rd degree hemorrhoids. Blood samples were taken to measure the ET-1 levels in subject’s serum and to compare the results with those for the control groups.

Results: Among the 90 subjects, 38 were male, and 52 were female. The average age was 36.8. The average ET-1 level marked 1.47 ± 0.78 pg/mL for male subjects and 1.16 ± 0.47 pg/mL for female subjects (P = 0.02). The average ET-1 level in the patient groups is as follow: 1.21 ± 0.44 pg/mL in group 1, 1.46 ± 0.83 pg/mL in group 2, and 1.20 ± 0.56 pg/mL in group 3 (P = 0.14).

Conclusion: Group 2, the chronic anal fissure patient group, showed a higher ET-1 level than groups 1 and 3, the control group and the hemorrhoid patient group, but this difference had no statistical significance.


Chronic anal fissure;Endothelin-1;Chronicity;Ischemia;Endothelium
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