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Clinical Significance of Lymph Node Ratio in Stage III Colorectal Cancer

대한대장항문학회지 2011년 27권 5호 p.260 ~ 265
 ( Park Yo-Han ) - 가톨릭대학교 의과대학 의정부성모병원 외과학교실

이재임 ( Lee Jae-Im ) - 가톨릭대학교 의과대학 외과학교실
박종경 ( Park Jong-Kyung ) - 가톨릭대학교 의과대학 외과학교실
 ( Jo Hang-Ju ) - 가톨릭대학교 의과대학 의정부성모병원 외과학교실
강원경 ( Kang Won-Kyung ) - 가톨릭대학교 의과대학 외과학교실
 ( An Chang-Hyeok ) - 가톨릭대학교 의과대학 의정부성모병원 외과학교실

Abstract


Purpose: Recent literature has shown that lymph node ratio is superior to the absolute number of metastatic lymph nodes in predicting the prognosis in several malignances other than colorectal cancer. The aim of this study was to evaluate the prognostic significance of the lymph node ratio (LNR) in patients with stage III colorectal cancer.

Methods: We included 186 stage III colorectal cancer patients who underwent a curative resection over a 10-year period in one hospital. The cutoff point of LNR was chosen as 0.07 because there was significant survival difference at that LNR. The Kaplan-Meier and the Cox proportional hazard models were used to evaluate the prognostic effect according to LNR.

Results: There was statistically significant longer overall survival in the group of LNR > 0.07 than in the group of LNR ≤ 7 (P = 0.008). Especially, there was a survival difference for the N1 patients group (LN < 4) according to LNR (5-year survival of N1 patients was lower in the group of LNR > 0.07, P = 0.025), but there was no survival difference for the N2 group (4 ≥ LN) according to LNR. The multivariate analysis showed that the LNR is an independent prognostic factor.

Conclusions: LNR can be considered as a more accurate and potent modality for prognostic stratifications in patients with stage III colorectal cancer.

키워드

Colorectal cancer;Metastatic lymph node ratio;Prognostic factor
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