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Does T3 Subdivision Correlate with Nodal or Distant Metastasis in Colorectal Cancer?

대한대장항문학회지 2012년 28권 3호 p.160 ~ 164
 ( Yoo Hong-Yeol ) - Seoul National University College of Medicine Department of Surgery

 ( Shin Ru-Mi ) - Seoul National University College of Medicine Department of Surgery
 ( Ha Heon-Kyun ) - Seoul National University College of Medicine Department of Surgery
 ( Oh Heung-Kwon ) - Seoul National University College of Medicine Department of Surgery
 ( Jeong Seung-Yong ) - Seoul National University College of Medicine Department of Surgery
 ( Park Kyu-Joo ) - Seoul National University College of Medicine Department of Surgery
 ( Kang Gyeong-Hoon ) - Seoul National University College of Medicine Department of Pathology
 ( Kim Woo-Ho ) - Seoul National University College of Medicine Department of Pathology
 ( Park Jae-Gahb ) - Seoul National University College of Medicine Department of Surgery

Abstract


Purpose: We analyzed the clinical data of T3 colorectal cancer patients to assess whether T3 subdivision correlates with node (N) or metastasis (M) staging and stage-independent factors.

Methods: Five hundred fifty-five patients who underwent surgery for primary colorectal cancer from January 2003 to December 2009 were analyzed for T3 subdivision. T3 subdivision was determined by the depth of invasion beyond the outer border of the proper muscle (T3a, <1 mm; T3b, 1 to 5 mm; T3c, >5 to 15 mm; T3d, >15 mm). We investigated the correlation between T3 subdivision and N, M staging and stage-independent prognostic factors including angiolymphatic invasion (ALI), venous invasion (VI) and perineural invasion (PNI).

Results: The tumors of the 555 patients were subclassified as T3a in 86 patients (15.5%), T3b in 209 patients (37.7%), T3c in 210 patients (37.8%) and T3d in 50 patients (9.0%). The nodal metastasis rates were 39.5% for T3a, 56.5% for T3b, 75.7% for T3c and 74.0% for T3d. The distant metastasis rates were 7.0% for T3a 9.1% for T3b, 27.1% for T3c and 40.0% for T3d. Both N and M staging correlated with T3 subdivision (Spearman’s rho = 0.288, 0.276, respectively; P < 0.001). Other stage-independent prognostic factors correlated well with T3 subdivision (Spearman’s rho = 0.250, P < 0.001 for ALI; rho = 0.146, P < 0.001 for VI; rho = 0.271, P < 0.001 for PNI).

Conclusion: Subdivision of T3 colorectal cancer correlates with nodal and metastasis staging. Moreover, it correlates with other prognostic factors for colorectal cancer.

키워드

T3 subdivision; Colorectal neoplasms; Neoplasm staging
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