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Prognostic Implication of 15-Hydroxyprostaglandin Dehydrogenase Down-Regulation in Patients with Colorectal Cancer

대한대장항문학회지 2012년 28권 5호 p.253 ~ 258
 ( Kang Pil-Sung ) - Chosun University College of Medicine Department of Surgery

 ( Kim Jin-Ha ) - Chosun University College of Medicine Department of Surgery
문옥인 ( Moon Ok-In ) - Chosun University College of Medicine Department of Surgery
 ( Lim Sung-Chul ) - Chosun University College of Medicine Department of Pathology
 ( Kim Kyung-Jong ) - Chosun University School of Medicine Department of Surgery

Abstract


Purpose: Prostaglandin (PG) E2 is known to be closely related to cancer progression and is inactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). 15-PGDH is shown to have tumor suppressor activity and to be down-regulated in various cancers, including colorectal cancer (CRC). Therefore, we evaluated the expression of 15-PGDH and its prognostic effect in patients with CRC.

Methods: 15-PGDH expression was examined by using immunohistochemistry in 77 patients with CRC. Its prognostic significance was statistically evaluated.

Results: Negative 15-PGDH expression was noted in 55.8% of the 77 cases of CRC. 15-PGDH expression showed no correlation with any of the various clinicopathologic parameters. The status of lymph node metastasis, tumor-node-metastasis stages, and pre-operative carcinoembryonic antigen levels showed significant prognostic effect. However, univariate analysis revealed down-regulation of 15-PGDH not to be a predictor of poor survival. The 5-year overall survival rate was 71.7% in the group with positive expression of 15-PGDH and 67.1% in the group with negative expression of 15-PGDH, but this difference was not statistically significant (P = 0.751).

Conclusion: 15-PGDH was down-regulated in 55.8% of the colorectal cancer patients. However, down-regulation of 15-PGDH showed no prognostic value in patients with CRC. Further larger scale or prospective studies are needed to clarify the prognostic effect of 15-PGDH down-regulation in patients with colorectal cancer.

키워드

Colorectal neoplasms; 15-hydroxyprostaglandin dehydrogenase; Down-regulation; Immunohistochemistry; Prognosis
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