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Association of Immune Status with Recurrent Anal Condylomata in Human Immunodeficiency Virus-Positive Patients

대한대장항문학회지 2012년 28권 6호 p.294 ~ 298
성지현 ( Sung Ji-Hyun ) - 국립중앙의료원 외과

안은정 ( Ahn Eun-Jung ) - 국립중앙의료원 외과
오흥권 ( Oh Heung-Kwon ) - 국립중앙의료원 외과
박세혁 ( Park Sei-Hyeog ) - 국립중앙의료원 외과

Abstract


Purpose: An anal condyloma is a proliferative disease of the genital epithelium caused by the human papillomavirus. This condition is most commonly seen in male homosexuals and is frequently recurrent. Some reports have suggested that immunosuppression is a risk factor for recurrence of a condyloma. Thus, we investigated the risk factors for a recurrent anal condyloma in human immunodeficiency virus (HIV)-positive patients.

Methods: We retrospectively analyzed 85 consecutive patients who were diagnosed with and underwent surgery for an anal condyloma from January 2007 to December 2011. Outcomes were analyzed based clinical and immunologic data.

Results: Recurrent anal condylomata were found in 25 patients (29.4%). Ten cases (40.0%) were within postoperative 3 months. At postoperative 6 months, the CD4 lymphocyte count in the recurrent group was lower than it was in the nonrecurrent group (P = 0.023).

Conclusion: CD4-mediated immunosuppression is a risk factor for recurrent anal condylomata in HIV-positive patients.

키워드

Condyloma accuminata; Human papillomavirus; HIV; Recurrence; Immunosuppression
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