medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis

대한대장항문학회지 2013년 29권 3호 p.93 ~ 99
 ( Kim Jeong-Yeon ) - Soonchunhyang University College of Medicine Department of Pathology

 ( Jeong Dong-Jun ) - Soonchunhyang University College of Medicine Department of Pathology
 ( Kim Hyung-Ju ) - Soonchunhyang University College of Medicine Department of Pathology
 ( Park Doo-San ) - Soonchunhyang University College of Medicine Department of Pathology
 ( Park So-Yong ) - Soonchunhyang University College of Medicine Department of Pathology
 ( Lee Sook-Young ) - Soonchunhyang University College of Medicine Department of Pathology
 ( Cho Hyun-Deuk ) - Soonchunhyang University College of Medicine Department of Pathology
 ( Ahn Tae-Sung ) - Soonchunhyang University College of Medicine Department of Surgery
 ( Lee Moon-Soo ) - Soonchunhyang University College of Medicine Department of Surgery
 ( Baek Moo-Jun ) - Soonchunhyang University College of Medicine Department of Surgery
 ( Bae Sang-Byung ) - Soonchunhyang University College of Medicine Department of Internal Medicine
 ( Lee Sung-Soo ) - Soonchunhyang University College of Medicine Department of Preventive Medicine

Abstract


Purpose: Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane-40 (BM-40), is a member of a family of matricellular proteins, whose functions are to modulate cell-matrix interactions, growth and angiogenesis in colorectal cancer. In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated.

Methods: The researchers analyzed the expression patterns of SPARC by using immunohistochemistry in 332 cases of colorectal cancer of tissue microarray. The clinicopathological characteristics were defined by using the TNM criteria of the Union for International Cancer Control. Clinicopathological factors such as age, sex, histologic type of the tumor, pathologic tumor stage, TNM stage, and lymphovascular invasion were evaluated according to the SPARC expression.

Results: The hazard ratios expressing SPARC in tumor cells, in the stroma, and in both tumor cells and the stroma were 2.10 (P = 0.036), 3.27 (P = 0.003) and 2.12 (P = 0.038), respectively. Patient survival was decreased in patient expressing SPARC in the stroma, and this result showed statistical significance (P = 0.016).

Conclusion: These findings suggest that SPARC expression in a tumor and in the stroma correlates with disease progression and may be used as a prognostic marker for colorectal cancer.

키워드

SPARC;Osteonectin;Colorectal neoplasms;Prognosis
원문 및 링크아웃 정보
  
등재저널 정보
KCI
KoreaMed
KAMS