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A Phase II Study of Additional Four-Week Chemotherapy With Capecitabine During the Resting Periods After Six-Week Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

대한대장항문학회지 2013년 29권 5호 p.192 ~ 197
 ( Lee Kyung-Ha ) - Chungnam National University Hospital Department of Surgery

송민상 ( Song Min-Sang ) - Chungnam National University Hospital Department of Surgery
 ( Park Jun-Boem ) - Chungnam National University Hospital Department of Surgery
 ( Kim Jin-Soo ) - Chungnam National University Hospital Department of Surgery
 ( Kang Dae-Young ) - Chungnam National University Hospital Department of Pathology
 ( Kim Ji-Yeon ) - Chungnam National University Hospital Department of Surgery

Abstract


Purpose: The aim of this study is to evaluate the efficacy and the safety of additional 4-week chemotherapy with capecitabine during the resting periods after a 6-week neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced rectal cancer.

Methods: Radiotherapy was delivered to the whole pelvis at a total dose of 50.4 Gy for 6 weeks. Oral capecitabine was administered at a dose of 825 mg/m2 twice daily for 10 weeks. Surgery was performed 2-4 weeks following the completion of chemotherapy.

Results: Between January 2010 and September 2011, 44 patients were enrolled. Forty-three patients underwent surgery, and 41 patients completed the scheduled treatment. Pathologic complete remission (pCR) was noted in 9 patients (20.9%). T down-staging and N down-staging were observed in 32 patients (74.4%) and 33 patients (76.7%), respectively. Grade 3 to 5 toxicity was noted in 5 patients (11.4%). The pCR rate was similar with the pCR rates obtained after conventional NCRT at our institute and at other institutes.

Conclusion: This study showed that additional 4-week chemotherapy with capecitabine during the resting periods after 6-week NCRT was safe, but it was no more effective than conventional NCRT.

키워드

Rectal neoplasms; Neoadjuvant therapy; Chemoradiotherapy; Capecitabine
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