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성호르몬이 백서전립선의 형태 및 Acid Phosphatase 활성도의 변동에 미치는 영향에 관한 실험적 연구

An Experimental Study on the Effects of Sex Hormones on the Morphology and Acid Phosphatase Activity of Prostate of Rats

대한비뇨기과학회지 1978년 19권 6호 p.509 ~ 524
최희석/Choi HS
김영균/Kim YK

Abstract


Sex hormones were administered to adult male rats ( Sprague-Dawley inbred line) with in tact gonads and with castration to study their influences on the morghological changes and acid phosphatase activities of the prostate.
1. Testosterone administered to normal and castrated rats caused marked increase in the wel gets of the prostates, while both estrogen administration and castration brought marked de cline of the prostatic weight.

2. Testosterone administration caused marked proliferation of the prostate, such as cystic hyperplasia and epithelial flattening of the acini, while estradiol, atrophy of the prostate. Such atrophy was also observed in castrated rats, but with the administration of testosterone the prostate resumed normal histologic picture.

3. The activities of acid phosphatase were highly pronounced histochemically in the ventral lobe of the prostate. These activities were dependent on sex hormones: decrease by estrogen and increase by testosterone. In castrated animals, the activities of the enzyme were almost negligeble, but with treatment of testosterone those activities resumed normal levels.

4. Estrogen administered to normal rats caused marked atrophy of the testis; decrease in the weight of the gland, atrophy of the germinal epithelium and decreased spermatogenesis.

키워드

전립선; 조직학; sex hormone; acid phosphatase; prostate; rat
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