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방광암에서 NF-κB와 Apoptosis 유발 유전자들에 관한 분석

Analysis of the NF-κB and Apoptosis Inducing Genes in Bladder Tumor

대한비뇨기과학회지 2007년 48권 5호 p.483 ~ 488
정필두 ( Jung Pil-Du ) - 충북대학교 의과대학 비뇨기과학교실

김용준 ( Kim Yong-June ) - 충북대학교 의과대학 비뇨기과학교실
이상철 ( Lee Sang-Cheol ) - 충북대학교 의과대학 비뇨기과학교실
김원재 ( Kim Wun-Jae ) - 충북대학교 의과대학 비뇨기과학교실
윤석중 ( Yun Seok-Joong ) - 충북대학교 의과대학 비뇨기과학교실
한광희 ( Han Kwang-Hee ) - 충북대학교 의과대학 비뇨기과학교실
이형래 ( Lee Hyung-Lae ) - 경희대학교 의과대학 비뇨기과학교실

Abstract


Purpose: A multi-subunit transcription factor NF-κB mediates the antiapoptotic signals in several cancer cell lines and it is activated in a broad range of human tumors. In this study, we investigated whether the expression levels of the NF-κB and the apoptosis inducing genes were related to the pathogenesis and clinical properties of human bladder tumor.

Materials and Methods: The expressions of NF-κB, BCL2-associated X protein(BAX), BCL2-associated death protein(BAD) and BH3-interacting domain death agonist protein(BID) were investigated by performing immunohistochemical staining on 133 archival bladder tissue paraffin blocks; these blocks included 122 transitional cell carcinomas of the urinary bladder and 11 normal bladder mucosae.

Results: The expression levels of NF-κB were significantly higher in the bladder tumors than those of the normal bladder mucosae(p=0.001). The expression levels of BAX in the superficial and low-grade(grade 1 and 2) bladder tumors were significantly enhanced more than those of the high-grade and invasive cases(p=0.042 and p=0.045, respectively), while the expression levels of BAD in the tumor tissues and low-grade tumors were significantly elevated compared with those of the normal mucosae and high grade tumor(p=0.007 and p=0.048, respectively). But the expressions of BID were not correlated with any pathologic and clinical properties.

Conclusions: The expressions of the NF-κB and apoptosis inducing genes such as BAX and BAD are strongly associated with the pathogenesis and clinical properties of bladder tumor. (Korean J Urol 2007;48:483-488)

키워드

NF-κB;BCL2-associated X protein;BCL2-associated death protein;BH3 interacting domain death agonist protein;Bladder tumor
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