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전립선 건강검진을 받은 60세 이상의 남성에서 대사증후군과 전립선용적의 연관성

The Relationship between Metabolic Syndrome and Prostate Volume in Men Over Sixties who Underwent Prostate Health Check-up

대한비뇨기과학회지 2008년 49권 9호 p.813 ~ 817
구교철 ( Koo Kyo-Chul ) - 연세대학교 의과대학 비뇨기과학교실

홍성준 ( Hong Sung-Joon ) - 연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
조강수 ( Cho Kang-Su ) - 연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
강은민 ( Kang Eun-Min ) - 연세대학교 의과대학 비뇨기과학교실
권성원 ( Kwon Sung-Won ) - 포천중문의과대학교 비뇨기과학교실

Abstract


Purpose: To evaluate the relationship between factors of metabolic syndrome(MS) to prostate volume and lower urinary tract symptom in men over sixties.

Materials and Methods: A total of 624 male subjects aged 60 to 90 years were enrolled. Prostate volume, urinary flow rate, voided volume, post void residual urine volume, voiding symptoms and MS-related parameters were investigated. Patients were divided into two groups; those with MS (n=223) and those without(n=401). Prostate volume, urodynamic factors and voiding symptoms were compared based upon MS categories.

Results: The MS and control group showed no significant differences with respect to age(74.8±5.6 vs. 74.0±5.4, respectively, p=0.083) and prostate specific antigen levels(1.8±1.5 vs. 1.7±1.5, respectively, p=0.248). However, the MS group had significantly greater waist circumference, blood pressure, fasting blood sugar level, hypertriglyceridemia and lower high density lipoprotein(HDL) cholesterol than the control group(p<0.05). Patients with MS showed significantly larger total prostate volume(p=0.008) and transitional zone volume(p=0.012). There were no differences between two groups respect to maximum flow rate, voided volume and residual volume (p>0.05). There was a significant relationship between prostate volume and obesity(p=0.016), however other MS factors such as low HDL, hypertension, non-insulin dependent diabetes mellitus and hypertriglyceridemia were not associated with prostate volume(p>0.05).

Conclusions: Metabolic syndrome is associated with prostate volume related factors, but not to voiding dysfunction in Korean men over sixties. Among subcategories of MS, obesity is the most strongly related factor to prostate volume.

키워드

Metabolic syndrome X;Prostatic hyperplasia;Urination disorders;Obesity
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