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Dutasteride를 투여받은 전립선비대증 환자에서 전립선특이항원 및 전립선특이항원 밀도의 변화

The Change of Prostate-specific Antigen and Prostate- specific Antigen Density in Patients with Benign Prostatic Hyperplasia after Dutasteride Treatment

대한비뇨기과학회지 2008년 49권 10호 p.893 ~ 898
김병석 ( Kim Byeong-Seok ) - 한양대학교 의과대학 비뇨기과학교실

박성열 ( Park Sung-Yul ) - 한양대학교 의과대학 비뇨기과학교실
문홍상 ( Moon Hong-Sang ) - 한양대학교 의과대학 비뇨기과학교실
최홍용 ( Choi Hong-Yong ) - 한양대학교 의과대학 비뇨기과학교실
손영우 ( Son Young-Woo ) - 한양대학교 의과대학 비뇨기과학교실
김용태 ( Kim Yong-Tae ) - 한양대학교 의과대학 비뇨기과학교실
윤영은 ( Yoon Young-Eun ) - 한양대학교 의과대학 비뇨기과학교실
이상봉 ( Lee Sang-Bong ) - 한양대학교 의과대학 비뇨기과학교실

Abstract


Purpose: Dihydrotestosterone(DHT) is key to the initiation and maintenance of abnormal prostatic growth in benign prostatic hyperplasia (BPH). Five α-reductase inhibitor reduces prostatic growth and serum prostate-specific antigen(PSA) by blocking the conversion of testosterone to DHT. Dutasteride is a dual(type 1 and 2) 5α-reductase inhibitor. We evaluated the effects of dutasteride on prostate volume, PSA, and PSA density in men with BPH.

Materials and Methods: A total of 83 men with a clinical diagnosis of BPH were treated with dutasteride and an alpha-blocker. We investigated the change in prostate volume, PSA, and PSA density 6 and 12 months after initiation of dutasteride therapy.

Results: After 6 months of dutasteride therapy, the total prostate volume was reduced from baseline by a mean of 15.46%, the PSA was reduced by a mean of 48.24%, and the PSA density was reduced by a mean of 37.97%(p<0.001). After 12 months of dutasteride therapy, the total prostate volume was reduced from baseline by a mean of 23.3%, the PSA was reduced by a mean of 52.57%, and the PSA density was reduced by a mean of 36.2%(p<0.001). There were no differences in the regression rate of PSA and PSA density, in contrast to prostate volume, between 6 and 12 months of dutasteride therapy by repeated measures ANOVA.

Conclusions: The findings in this study demonstrate that the actual PSA in men receiving dutasteride would be multiplied by 2 considering the PSA regression rate after 12 months.

키워드

5α-reductase inhibitor;Dutasteride;Prostate-specific antigen
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