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OK-432를 이용한 단순 신낭종의 경피적 경화요법

Treatment of Simple Renal Cysts by Percutaneous Aspiration and OK-432 Sclerotherapy

대한비뇨기과학회지 2008년 49권 10호 p.917 ~ 922
박성진 ( Park Sung-Jin ) - 연세대학교 의과대학 비뇨기과학교실

김원태 ( Kim Won-Tae ) - 연세대학교 의과대학 비뇨기과학교실
조성용 ( Cho Soung-Yong ) - 인제대학교 의과대학 비뇨기과학교실
이동훈 ( Lee Dong-Hoon ) - 연세대학교 의과대학 비뇨기과학교실
조강수 ( Cho Kang-Su ) - 연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
함원식 ( Ham Won-Sik ) - 연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
최영득 ( Choi Young-Deuk ) - 연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소

Abstract


Purpose: Percutaneous aspiration with sclerotherapy has been widely used for the treatment of symptomatic or large simple renal cysts. Ethanol has been most commonly used as a sclerosing agent; however, a temporary percutaneous nephrostomy for multiple ethanol injections is necessary to achieve a low recurrence rate. Thus, we used OK-432 as a new sclerosing agent without a temporary percutaneous nephrostomy for multiple injections, and also compared our results with the results of previous studies.

Materials and Methods: Between October 2005 and April 2006, 50 patients (63 simple renal cysts) who underwent percutaneous OK-432 sclerotherapy for simple renal cysts were evaluated. The simple renal cysts were aspirated under ultrasonography and fluoroscopy, after which OK-432 was injected into the cyst. Follow-up was performed with ultrasonography or CT scan after 3 months. Regression of the renal cyst or a >70% reduction in size with no symptoms was considered a treatment success.

Results: Among 63 renal cysts in 50 patients, complete regression occurred in 17(27.0%). Greater than a 90% reduction in size occurred in 8(12.7%), a 80-90% reduction in size occurred in 21(33.3%), and a 70-80% reduction in size occurred in 15(23.8%); a <70% reduction in size occurred in 2 (3%). The overall efficacies of success were 96.8%. After the procedure, there were only some minor complications, such as mild fever, local pain, and liver function test elevation that subsided with symptomatic treatment.

Conclusions: Percutaneous OK-432 sclerotherapy is simple, safe, and effective and can be an alternative first-line therapy of simple renal cysts.

키워드

Renal cyst;OK-432;Sclerotherapy
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