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흰쥐에서 일측 고환염전과 염전복구 후의 환측 및 대측 고환과 부고환의 조직학적 변화

Histologic Alterations in the Ipsilateral and Contralateral Testes and Epididymides of Rats following Unilateral Torsion and Detorsion of the Testes

대한비뇨기과학회지 2008년 49권 10호 p.945 ~ 952
백민기 ( Baek Min-Ki ) - 건국대학교 의과대학 비뇨기과학교실

백성현 ( Paick Sung-Hyun ) - 건국대학교 의과대학 비뇨기과학교실
오승준 ( Oh Seung-June ) - 서울대학교 의과대학 비뇨기과학교실
홍성규 ( Hong Sung-Kyu ) - 서울대학교 의과대학 비뇨기과학교실
전윤경 ( Jeon Yoon-Kyung ) - 서울대학교 의과대학 병리학교실
정성진 ( Jeong Seong-Jin ) - 서울대학교 의과대학 비뇨기과학교실
박인애 ( Park In-Ae ) - 서울대학교 의과대학 병리학교실
최황 ( Choi Hwang ) - 서울대학교 의과대학 서울대학교병원 비뇨기과학교실

Abstract


Purpose: This investigation was undertaken to determine the damage to the testes and epididymides following torsion and detorsion of the testes.

Materials and Methods: The right testes of 8-week-old male rats(n=30) were subjected to torsion for 10 min. At 0, 1, 4, 8, and 24 hours, and 1 week after the repair of a torsion, the ipsilateral and contralateral testes and epididymides were harvested. The mean number of spermatids per tubule, the mean seminiferous tubular diameter(MSTD), and the germinal epithelial cell thickness(GECT) were used to evaluate changes to the testes. The histologic changes to the epididymal ductal epithelium were also evaluated.

Results: The mean number of spermatids per tubule, GECT, and MSTD were significantly decreased in the 24-hour ipsilateral detorsion group, but minimal changes to ipsilateral testes were observed in the 1-week detorsion group. There was no evidence of histologic changes to the testes in any of the contralateral detorsion groups. The interstitial fibroblast proliferation and hemorrhage of the ipsilateral epididymis were found in the 4-hour detorsion group and increased in the 8-hour detorsion group. Interstitial fibroblast proliferation was prominent in the ipsilateral epididymis of the 24-hour detorsion group, but was only occasionally observed in the contralateral epididymides. Shortening of the tubular epithelial cell height and tubule dilatation were observed in the ipsilateral and contralateral epididymis 1 week after detorsion.

Conclusions: Torsion/detorsion damage was found earlier and at a higher intensity in the epididymides than in the testes. This finding may be due to the protection afforded by the blood-testis barrier.

키워드

Testis;Epididymis;Testicular torsion
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