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Expression of Claudin-1 and -7 in Clear Cell Renal Cell Carcinoma and Its Clinical Significance

대한비뇨기과학회지 2011년 52권 5호 p.317 ~ 322
신홍일 ( Shin Hong-Il ) - Keimyung University School of Medicine Department of Urology

김병훈 ( Kim Byung-Hoon ) - Keimyung University School of Medicine Department of Urology
장혁수 ( Chang Hyuk-Soo ) - Keimyung University School of Medicine Department of Urology
김천일 ( Kim Chun-Il ) - Keimyung University School of Medicine Department of Urology
정혜라 ( Jung Hye-Ra ) - Keimyung University College of Medicine Department of Pathology
박철희 ( Park Choal-Hee ) - Keimyung University School of Medicine Department of Urology

Abstract


Purpose: We investigated the correlations between the expression of claudin-1 and claudin-7 in clear cell renal cell carcinoma (clear cell RCC) and clinical parameters.

Materials and Methods: The subjects of this study were 119 patients with confirmed clear cell RCC between January 2000 and December 2007. Their RCC tissues were immunohistochemically stained for claudin-1 and claudin-7. The correlations between the expression of claudin and parameters such as sex, age, body mass index (BMI), tumor size, TNM stage, Furhman nuclear grade, postoperative distant metastasis, and cancer-specific survival were analyzed.

Results: Among the total 119 subjects, claudin-1 was expressed in 18 (15.1%) and claudin- 7 in 31 (26.1%). Claudin-1 was expressed in patients who were older (p=0.007), who had a greater tumor size (p=0.001), who had a higher pathologic T stage (p=0.009), who had preoperative distant metastasis (p=0.035), and who had a higher Furhman nuclear grade (p=0.004). Claudin-7 was expressed only in patients who had a higher Furhman nuclear grade (p=0.031). The risk of postoperative distant metastasis was associated with the expression of claudin-1 (p<0.001) but not with the expression of claudin-7 (p=0.668). The expression of claudin-1 and -7 was not associated with cancer-specific survival (p>0.05).

Conslusions: In clear cell RCC, claudin-1 was expressed in patients who were older and who had a greater tumor size, who had higher T or M stages, and who had a higher Furhman nuclear grade. The expression of claudin-1 was associated with a higher risk of postoperative distant metastasis.

키워드

Claudin 1; Claudin 7; Renal cell carcinoma
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