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Preoperative Erythropoietin Administration in Patients With Prostate Cancer Undergoing Radical Prostatectomy Without Transfusion

대한비뇨기과학회지 2014년 55권 2호 p.102 ~ 105
 ( Lee Byung-Woo ) - Inje University Seoul Paik Hospital Department of Urology

 ( Park Seok-San ) - Inje University Haeundae Paik Hospital Departments of Urology
 ( Yeo Jeong-Kyun ) - Inje University Seoul Paik Hospital Department of Urology
 ( Park Min-Gu ) - Inje University Seoul Paik Hospital Department of Urology
 ( Cho Dae-Yeon ) - Inje University Seoul Paik Hospital Department of Urology

Abstract


Purpose: In this study, we administered erythropoietin preoperatively to patients who underwent open radical prostatectomy without transfusion to increase their hemoglobin levels and investigated the efficacy of this procedure.

Materials and Methods: We evaluated 62 patients who underwent open radical prostatectomy performed by the same surgeon between June 2005 and January 2011. The 22 patients who refused transfusion were assigned to group 1; the patients who accepted transfusion were assigned to group 2. Before surgery, we administered erythropoietin beta to group 1 patients whose hemoglobin levels were <12 g/dL and retrospectively compared the clinical data of the two groups. We used the t-test and the chi-square test for statistical analysis.

Results: Mean preoperative hemoglobin levels in group 1 after erythropoietin administration (14.5 g/dL) were significantly higher than those in group 2 (13.59 g/dL, p=0.003). Moreover, the difference in the mean hemoglobin levels before and after surgery for group 1 patients (3.55 g/dL) significantly exceeded that for group 2 patients (2.08 g/dL, p=0.000). Additional analysis revealed no statistically significant differences in perioperative complications between the groups.

Conclusions: Preoperative erythropoietin administration increased the safety margin of hemoglobin levels, and this strategy worked sufficiently well in our experience.

키워드

Blood transfusion; Bloodless medical and surgical procedures; Erythropoietin; Jehovah’s witnesses; Prostatectomy
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