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Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer

대한비뇨기과학회지 2015년 56권 6호 p.435 ~ 442
 ( Taverna Gianluigi ) - Humanitas Clinical and Research Hospital Department of Urology

 ( Grizzi Fabio ) - Humanitas Clinical and Research Hospital Inflammation and Immunology
 ( Colombo Piergiuseppe ) - Humanitas Clinical and Research Hospital Department of Pathology
 ( Seveso Mauro ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Giusti Guido ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Proietti Silvia ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Fiorini Girolamo ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Lughezzani Giovanni ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Casale Paolo ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Buffi Nicolo ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Lazzari Massimo ) - Humanitas Clinical and Research Hospital Department of Urology
 ( Guazzoni Giorgio ) - Humanitas Clinical and Research Hospital Department of Urology

Abstract


Purpose: Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkers with improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexity in prostate tumor and nontumor biopsy cores by use of a computer-aided image analysis system and assessed the correlations between the results and selected clinical and pathological parameters of prostate carcinoma.

Materials and Methods: A total of 280 prostate biopsy sections from a homogeneous series of 70 patients with low-risk prostate cancer (Gleason score 3+3, prostate-specific antigen [PSA]<10 ng/mL, and clinical stage T1c) who underwent systematic biopsy sampling and subsequent radical prostatectomy were analyzed. For each biopsy, 2-μm sections were treated with CD34 antibodies and were digitized by using an image analysis system that automatically estimates the surface fractal dimension.

Results: Our results showed that biopsy sections without cancer were significantly more vascularized than were tumors. No correlations were found between the vascular surface fractal dimension and patient’s age, PSA and free-to-total PSA ratios, pathological stage, Gleason score, tumor volume, vascular invasion, capsular penetration, surgical margins, and biochemical recurrence.

Conclusions: The value of angiogenesis in prostate cancer is still controversial. Our findings suggest that low-risk prostate cancer tissues are less vascularized than are nontumor tissues. Further studies are necessary to understand whether angiogenesis is a hallmark of intermediate- and high-risk prostate cancer.

키워드

Biological markers ; Blood vessels ; Neoplasms ; Prostate
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