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絨毛腫瘍에 對한 藥物治療의 考察

Chemotherapy of Trophoblastic Tumor

대한산부인과학회지 1967년 10권 3호 p.13 ~ 18
金斗相/Kim, Doo Sang
片址洙/金孝淑/Pyun, Ji Soo/Kim, Hyo Sook

Abstract


Methotrexate treatments were done for 4 cases of metastatic choriocarcinoma and one case of chorioadenoma destruens, with the result that the complete clinical healing was gained in one, while in 4 the resistance to methotrexate treatment developed.
The followings are the summary of the results:
1) It seems that delayed initiation of treatment is followed with more liable resistance formation.
2) Effect of methotrexate was more pronounced on the vaginal metastatic growth than the pulmonary metastasis. The vaginal new growth could not be observed even after the resistance developed, whereas in the lung new growth or exacerbation of the old tumor could be observed.
3) The repeated cures or increments of the drug were not effective to reduce the resistance to methotrexate. Review of the literature and author´s own clinical experience showed that treatment in methotrexate-resistant cases should be switched on other anticarcinogenic agent.
4) Formation of resistance to methotrexate can reasonably be judged by Friedman rabbit unit, when the unit remains unchanged even after 2 cycle treatment of methotrexate or the suppressed unit shows increase with cessation of treatment or even under methotrexate regimen.

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