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인위적 유발에 의한 난소 간질선의 기원에 관한 연구

Studies on the Histogenesis of the Experimentally Induced Ovarianinterstitial Glands

대한산부인과학회지 1976년 19권 11호 p.827 ~ 831
박문성 (  ) - 국립원호병원 산부인과

Abstract


The interstitial cells of the human ovaries were began to appear in late fourth decade thereafter increased in number and were ascribed to hormonal secretion in menopaused woman and they were especially well developed in rodents and formed acinar structures in them(Lee and Kim, 1965; Richardson, 1966). And such interstitial glands in the rodents could be induced by administration of formalin as stressor (Lee and Kim, 1965) and induced by autotranspiantation of the ovary into the spleen of the spayed mice (Park and Kim, 1973). And the regenerated ovarian tissue within the spleen had some amounts of mucosubstances (Choen and Kim, 1975).
Therefor the author try to search the histogenesis of interstitial glands within the autotransplanted ovaries into the spleen of spayed mice by various histochemical techniques. Pregestrous mice (8=10gm in weight and within 3 weeks after birth) were spayed, the left ovary were autotransplanted into the spleen and were kept for 1; 3, 5, 7, 9, 11, 13, 15,17 and 19 days.
Paraffine sections were made acording to routine histologic methods and several kinds of staining for mucosubstances and for collagen fibers were made. The followings were ensued.
1. The ovarian transplants were undergone necrotic changes 1 day after transplantation and began to regenerated 7 days after transplantation.
2. The degree of the regeneration within the ovarian transplants were almostly complete in degree.
3. During the changes of the unrippened´ follicle into the atretic follicle, there were swelling of the theca cells and thosecells were released into the ovarian stroma and acigar structures, i. e. interstitial glands.

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