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염색체이상의 산전진단시 이용되는 융모막 융모채취에 관한 연구

A Study of Chorionic Villus Sampling for Prenatal Diagnosis of Chromosomal Abnormalities

대한산부인과학회지 1993년 36권 8호 p.3231 ~ 3240
채규정
이민아/이용/김승일/진소자

Abstract


Chorionic villus sampling (CVS) is a method of prenatal diagnosis in the first timester of pregnancy in which tissue for genetic study is aspirated from the developing placenta by means of a catheter inserted transcervically or transabdominally
under
the guidance of ultrasonography.
CVS has the advantage over second trimester amniocentesis of allowing earlier prenatal diagnosis of genetic and chromosomal disorders in the fetus but the relative safety and diagnostic accuracy remain unclear.
From Apr. 1990 to Sep. 1992, 305 women who they visited Department of Ob & Gyn of Chunbuk National University Hospital seeking prenatal diagnosis of chromosomal disorders were recruited to compare the safety and diagnostic accuracy of the two
techniques.
@ES The results obtained were as follows;
@EN 1. Failure rate of cytogenetic analysis was 10.9% in CVS and 5.0% in amniocentesis(p<0.05).
2. Incidence of pseudomosaicism was 4.1% in CVS and 3.8% in amniocentesis.
3. When placenta (chorionic frondosum) was located on the fundus of uterus, failure rate of CVS 40.0% (P<0.01), so location of chorionic frondosum seems to play a major role in success of trancervical CVS.
4. Fetal loss(<28 wks) occurred 5 cases(3.0%) in CVS and 3 cases(2.1%) in amniocentesis, but there was no statistical significance(P=NS).
As a results, We conclude that CVS is an effective and safe method for early prenatal diagnosis of chromosomal abnormalities, but that it probably entails a slightly higher risk of procedure failure and of fetal loss than does amniocentesis.

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