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상피성 난소암 환자에 있어서 면역조직화학 검사법을 이용한 c-erbB-2 단백 과발현에 관한 연구

An Immunohistochemical Evaluation of c-erbB-2 Expression in Epithelial Ovarian Cancer

대한산부인과학회지 1993년 36권 8호 p.3334 ~ 3342
김경태
조삼현/황윤영/문형/이재억/고영혜/이중달

Abstract


Previous studies have suggested that overexpression of c-erb B-2 oncogene occurs in 15~40 of breast cancers and that overexpression is associated with poor survival. In the present study, we have used an immunohistochemical technique involving a
polyclonal antibody specifically reactive with external domain of c-erb B-2 to study expression of c-erb B-2 in paraffin embedded sections of normal ovary(5) and epithelial ovarian cancer(42). The intensity of staining for c-erb B-2 was always
moderated
or less (0~2+) in normal ovarian epithelium. Among 42 ovarian cancers, 31(77.8%) had staining similar to that for normal ovarian epithelium (0~2+) while 11 (26.2%) had staining heavily(3+). Survival of the 11 patients with high c-erb B-2
expression
was
significantly worse than that of the 31 patients with normal c-erb B-2 expression. (5-year survival :81% vs 45% (p=0.0491), median survival:34vs 43 months(p=0.0485)) In addition, patients whose tumors had high c-erb B-2 expression were
significantly
less likely to have a complete response to primary theraty or have a negative second look laparotomy. These findings suggest that overexpression of c-erb B-2 oncoprotein may be associated with poor survival in epithelial ovarian cancer and c-erb
B-2
deserves further evaluation as a prognostic marker in epithelial ovarian cancer.

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