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Placental Site Trophoblastic Tumor의 임상병리학적 특정에 관한 연구

Clinicopathological Correlation in Placental Site Trophoblastic Tumor

대한산부인과학회지 1994년 37권 3호 p.520 ~ 527
정기욱
신희정/이원회/나덕진/남궁성은/정재근/김승조/이헌영

Abstract


Placental site trophoblastic tumor (PSTT) is a rare from of gestational trophoblastic disease and the patients with a placental site trophoblastic tumor clearly present a wide range of clinical courses. Because of its apparent benign nature, it
was
originally termed trophoblastic pseudotumor of the uterus. The name was later changed when cases were reported of metastatic tumors resistant to chemotherapy leading to the death of the patients. We have studied clinicopathological study on
placental
site trophoblastic tumor correlation of PSTT in 4 patients from January 1986 to December 1991 at Department of Obstetrics and Gynecology, Catholic University Medical College and
@ES the results were as follows:
@EN 1. The mean age of PSTT was 28 years old and mean parity was 0.75.
2. The antecedent pregnancy ended in term pregnancy in two patients, H-mole in one patient and premature, preeclampsia with congenital anomaly in one patient.
3. The interval from the antecedent pregnancy to diagnosis of PSTT ranged from 10 to 28 (mean 16.8%) months.
4. presenting symptom was vaginal spotting in 3 patients and secondary amenorrhea in one patient.
5. Pretreatment hCG levels obtained in 3 patients ranged 28~858 mIU/ml but one patient have a high value as 13,480 mIU/ml. The pretreatment hPL levels obtained in 1 patients was a 0.1mg/ml.
6. All four were diagnosed as having a PSTT by endometrial currettage and all were initially determined to have nonmetastatic lesion.
7. Two patients were treated by total abdominal hysterectomy and adjuvant chemotherapy and two patients were treated with chemotherapy only.
All four have remained in clinical and gonadotropin remission and two of them have outcome of normal pregnancy.

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