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정상체중아, 저체중아, 과체중아 및 조산아의 제대혈청내 인슐린유사 성장인자 결합단백질들의 양상

Insulin-like Growth Factor Binding Proteins(IGFBPs) Profiles in Cord Sera of Appropriate-for-gestational Age, Small-for-gestational Age, Large-for-gestational Age infant and Preterm Infant

대한산부인과학회지 1997년 40권 3호 p.581 ~ 590
김정구
구승엽/김석현/최영민/신창재/문신용/이진용

Abstract


The insulin-like growth factor(IGF) system consists of IGFs, their receptor and binding proteins(IGFBPs). The IGFs are important growth factors in the regulation of fetal growth. Since IGFBPs control IGF actions, the IGFBPs themselves may also be
important in fetal growth and development. The goals of this study are to investigate the profiles of IGFBPs in cord sera of appropriate-for-gestational age(AGA, n=27), small-for-gestational age(SGA, n=14), large-for-gestational age(LGA, n=10)
infants
and preterm(PT, n=14) infants and to evaluate the relationship between these IGFBP levels and gestational weeks and birth weight and between total IGFBP levels in cord sera and paired maternal sera(n=65). The IGFBPs were analyzed by Western
ligand
blot
and immunoprecipitation. In cord sera of AGA infants IGFBPs with molecular weight with 37/43 kilodaltons(kDa ; IGFBP-3), k31 kDa(IGFBP-2), 26 kDa(IGFBP-1), 24 kDa(IGFBP-4) were detected. In cord sera of LGA infants there was a significant
increase
in
IGFBP-3 levels and a reduction of IGFBP-1 and IGFBP-4 levels compared with those in AGA infants. SGA infants had significantly higher IGFBP-1 and IGFBP-2 levels in cord sera than AGA infants. There was a similar trend in IGFBP-1 levels in cord
sera
of
PT infants. The relative proportion of IGFBP-4 in cord sera of SGA and PT infants was significantly higher than that of AGA infants. There was no significant correlation between total IGFBP levels in cord sera and paired maternal sera. The ratios
of
total IGFBP in cord sera to that in maternal sera were significantly higher in SGA and PT infants than in AGA infants. The IGFBP-1 and IGFBP-2 levels correlated with birth weight but did not correlate with gestational weeks.
These data suggest that there is an unique profile of IGFBPs in cord sera of infants according to their weight, and that IGFBPs may play a major role in the control of fetal growth.

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