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분만전후 산모에서 급성반응물질로서 혈중 Lipoprotein(a)의 농도변화

Changes of Plasma Lipoprotein(a) Levels as a Acute Phase Reactant from Antepartum to Postpartum Period

대한산부인과학회지 1997년 40권 3호 p.599 ~ 605
이재찬 (  ) - 중앙대학교

이인수 (  ) - 중앙대학교
장은하 (  ) - 중앙대학교
이유복 (  ) - 중앙대학교

Abstract


Lipoprotein(a)[Lp(a)] represents a class of lipoprotein particle defined by the presence of apolipoprotein(a), a unique glycoprotein linked by a disulfide bond to apolipoprotein B-100 to form a single macromolecule. It was known that Lp(a) levels
were
associated with risk factor for cardiovascular disease and were fluctuated during pregnancy and postpartum.
In the present study, plasma Lp(a) levels were estimated in two groups of women comprising 48 normal spontaneous vaginal delivery group and 52 Cesarean section delivery group. The changes of plasma Lp(a) concentrations were serially estimated
before
delivery, postpartum 1 weeks and postpartum 6 weeks.
@ES The result can be summarized as follows.
@EN 1. Mean ploasma Lp(a) levels were changed from 43.9±28.4mg/dl at delivery to 68.5±3535mg/dl at postpartum 1 weeks, 45.6±26.4 mg/dl at postpartum 6 weeks in total delivery group.
2. Before delivery, mean plasma Lp(a) levels were 48.9±25.4mg/dl in NSVD group versus 39.2±30.4 mg/dl in C/S group, with a rising level after postpartum 1 weeks 73.1±35.7 mg/dl versus 63.7±35.1mg/dl. And after postpartum 6 weeks, mean plasma
Lp(a)
levels were returned to near initial levels 48.4±21.1 mg/dl versus 42.2±16.7mg/dl.
3. Lp(a) levels were significantly rised postpartum 1 weeks compared with before delivery(p<0.05) and after postpatum 6 weeks(p<0.05).
In conclusion, serum Lp(a) levels were increased postpartum 1 weeks with significant value, and returned to initial levels after postpartum 6 weeks. Our findings suggests that Lp(a) has the characteristics of an acute phase reactant rather
modulated by
endogenous hormone.

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