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과배란유도 성숙난포액내의 Insulin-like Growth Factor-I(IGF-I), Insulin-like Growth Factor Binding Protein-3(IGFBP-3), Growth Hormone(GH) 및 Estradiol(E2)과의 상호관계

Correlations amongst Insulin-like Growth Factor-I(IGF-I), Insulin-like Growth Factor Binding Protein-3(IFBP-3), Growth Hormone(GH) and Estradiol(E2) in Follicular Fluid of the Patients with Ovulation Induction

대한산부인과학회지 1997년 40권 3호 p.606 ~ 613
이용주
배상욱/정창진/김동현/장경환/이병석/박기현/조동제/송찬호

Abstract


Recently, the ovary is known to be a center of paracrine and autocrine regulating factors.
IGF-I is a local regulator of follicular function and a potent stimulator of ovarian cell proliferation and differentiation, in synergy will the gonadotrophins, whilst GH may exert its effect by changing intra-ovarian IGF-I concentration. In
biological
fluids, IGFs are bound to specific, high affinity binding proteins(IGFBP0. The IGFBPs are considered as paracrine modulators of the action of IGF-I in the ovary.
The aim of the study is to elucidate relationships amongst IGF-I, IGFBP-3, GH and estradiol in mature follicular fluids or serum. Thirty-six infertility patients who underwent ovulation induction program by GnRH agonist short or long protocol for
in
vitro fertilization (IVF) were examined to investigate the correlations amongst the concentration of IGF-I, IGFBP-3, GH and estradiol in follicular fluid or serum. These hormones were quantitatively analyzed by radioimmunoassay(RIA) of
Immunoradiometric
assay(IRMA). There were statistically significant correlations between the concentration of IGF-I and GH, IGFBP-3 in follicular fluid.
Therefore, GH tends to increase IGF-I levels in follicular fluid and IGF-I may functions as an important regulator of IGFBP-3 synthesis in follicular fluid, but IGFBP-3 is not likely to be under the direct control of GH in follicular fluid.

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