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생식선 이상발생을 동반한 조기난소부전 1예

A Case of Premature Ovarian Failure Associated with Gonadal Dysgenesis

대한산부인과학회지 1999년 42권 1호 p.138 ~ 141
남윤성/Yoon Sung Nam
이숙환/곽인평/윤태기/차광열/Sook Hwan Lee/In Pyung Kwak/Tae Ki Yoon/Kwang Yul Cha

Abstract

결론
저자들은 조기난소부전 환자에서 Y염색체가 X염색체로 전좌된 생식선 이상발생 1예를
경험하였기에 문헌고찰과 함께 보고하는 바이다.

Premature ovarian failure is a condition causing amenorrhea, hypoestrogenism, and
elevated genadotropins in women younger than 40 years. A karyotype should be
performed as part of basic laboratory evaluation for all patients with premature ovarian
failure and prodromal premature ovarian failure.
Development of a malignancy in a dysgenetic gonad is of major concern. The
presence of a fragment of the Y chromosome is thought to be a key to the oncogenic
potential of these gonads. The search for the testicular determining factor(TDF) has
engendered much confusion about which part of the Y chromosome plays a role in
malignancy. This was initially postulated to be the H-Y antigen. More recent data,
however, localize the area rear the centromere of the Y Chromosome, on the long
arm(Yq). Malignant potential is clearly not linked to the testicular determining factor
itself(SRY). This is a critical point in clinical medicine. Feilure to display SRY or a
closely related sequence does not rule out the presence of the segment of the Y
chromosome postulated to be associated with the development of malignancies.
We have experienced a case of premature ovarian failure with chromosomal
abnormality involving Y chromosome fragment. So we report this case with a brief
review of literatures.

키워드

Premature ovarian failure; Gonadal dysgenesis;
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