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한국인 여성에서 중증 자궁내막증의 발생 위험도와 CYP17 유전자 다형성과의 관련성에 관한 연구

Association of the CYP17 gene polymorphism with the risk of advanced endometriosis in Korean women

대한산부인과학회지 2005년 48권 3호 p.695 ~ 700
허성은/Hur SE
김미경/이사라/이지영/문혜성/정혜원/Kim MK/Lee SR/Lee JY/Moon HS/Chung HW

Abstract


Objective: To investigate whether polymorphism of CYP17 gene is associated with the risk of advanced endometriosis in Korean women.

Methods: The 194 endometriosis patients and 209 controls were enrolled. Blood samples were collected from 194 patients with endometriosis stages III and IV diagnosed by both pathologic and laparoscopic findings. The women undergoing laparoscopic surgery or laparotomy for non-malignant lesions were included in the control group. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals’ genotype.

Results: The heterozygous allele in CYP17 gene was most common genotypes in both endometriosis and healthy control groups (54.6% vs. 38.8%). In women with heterozygous A1/A2 genotype, there was increased endometriosis risk and this difference was statistically significant (p<0.05).

Conclusion: The results suggest that the CYP17 genetic polymorphism might be associated with advanced endometriosis risk in Korean women.

키워드

자궁내막증;유전자 다형성;CYP17;Endometriosis;Polymorphism
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