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자궁내막증 환자에서 자궁내막의 표피성장인자 및 섬유아세포성장인자-2 mRNA의 발현 양상

The expression of epidermal growth factor and fibroblast growth factor-2 in the eutopic endometrium of women with endometriosis

대한산부인과학회지 2005년 48권 3호 p.701 ~ 708
최정원/Choi JW
이향아/이사라/홍석호/나희영/이영진/김성훈/채희동/김정훈/강병문/Lee HA/Lee SR/Hong SH/Na HY/Lee YJ/Kim SH/Chae HD/Kim CH/Kang BM

Abstract


Objective: To compare the expression of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) in the eutopic endometrium of women with and without endometriosis.

Methods: Thirty-two women with histologically confirmed endometriosis after laparotomy or laparoscopy were recruited. Twenty-eight women with carcinoma in situ of the uterine cervix, uterine myoma and ovarian tumor but no evidence of endometriosis served as control. Following isolation of total RNA from endometrial tissue and reverse transcription, cDNA samples were amplified by real time PCR to quantify the expression of EGF, FGF-2, and GAPDH genes.

Results: Including all menstrual phases, the levels of mRNA expressions of EGF and FGF-2 were not different between the eutopic endometrium of women with and without endometriosis. When analyzed separately according to the 6 menstrual phases, no differences were found between the two groups, either.

Conclusion: This study shows that the levels of mRNA expressions of EGF and FGF-2 in the eutopic endometrium were not different between women with and without endometriosis.

키워드

표피성장인자;섬유아세포성장인자-2;자궁내막;자궁내막증;맥관형성;EGF;FGF-2;Endometriosis;Endometrium;Angiogenesis
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