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자간전증에서 제대정맥혈장내 interleukin-6, tumor necrosis factor-α, 및 항산화제 농도

Interleukin-6, tumor necrosis factor-α, and antioxidant levels in the umbilical venous plasma of preeclampsia

대한산부인과학회지 2007년 50권 7호 p.982 ~ 990
김윤하 ( Kim Yoon-Ha ) - 전남대학교 의과대학 산부인과학교실

김석모 ( Kim Seok-Mo ) - 전남대학교 의과대학 산부인과학교실
조문경 ( Cho Moon-Kyoung ) - 전남대학교 의과대학 산부인과학교실
김기민 ( Kim Ki-Min ) - 전남대학교 의과대학 산부인과학교실
김철홍 ( Kim Cheol-Hong ) - 전남대학교 의과대학 산부인과학교실
송태복 ( Song Tae-Bok ) - 전남대학교 의과대학 산부인과학교실
정광필 ( Jeong Kwang-Pil ) - 전남대학교 의과대학 산부인과학교실
김종운 ( Kim Jong-Woon ) - 전남대학교 의과대학 산부인과학교실
안봉환 ( Ahn Bong-Whan ) - 전남대학교 의과대학 생화학교실
양성렬 ( Yang Sung-Yeul ) - 전남대학교 의과대학 생화학교실
박소정 ( Park So-Jeong ) - 전남대학교 의과대학 산부인과학교실
박지노 ( Park Ji-No ) - 전남대학교 의과대학 산부인과학교실

Abstract


Objective: Our purpose was to investigate Interleukin-6 (IL-6), tumor necrotic factor-alpha (TNF-alpha), lipid peroxide levels, oxygen-radical absorbance capacity (ORAC), and antioxidant levels in umbilical venous blood plasma and to evaluate the roles of them in the pathophysiology of preeclampsia.

Study design : Samples of umbilical venous plasma were obtained from 20 normal and 20 preeclamptic women between 33 and 40 weeks gestation. IL-6 and TNF-alpha was assayed by an enzyme-linked immunoassay. Lipid peroxide levels were measured by thiobarbituric acid reaction. The ORAC values were measured by Cao’s method. Ascorbic acid, retinol, alpha-tocopherol, and gamma-tocopherol were measured by high performance liquid chromatography.

Results: There was no significant differences of IL-6 levels in umbilical venous plasma between women with normal and preeclampsia (2.79+/-0.21 vs. 2.94+/-0.17 ng/ml). TNF-alpha levels in umbilical venous plasma of women with preeclampsia were significantly higher than that of women with preeclampsia (3.04+/-0.01 vs. 1.40+/-0.01 ng/ml, p<0.01). Lipid peroxide levels in umbilical venous plasma of women with preeclampsia were significantly higher than that of women with normal pregnancy (7.32+/-0.09 vs. 5.18+/-0.14, p<0.01). The ORAC values in umbilical venous plasma of women with preeclampsia were significantly lower than that of women with normal pregnancy (12,836.5+/-249.4 vs. 10,490.2+/-276.9 U/ml, p<0.05). Ascorbic acid levels in umbilical venous plasma of women with preeclampsia were significantly lower than those of women with normal pregnancy (320.2+/-48.5 vs. 538.5+/-68.2 nmol/ml, p<0.05).
Conclusion: The above results in umbilical venous plasma suggest that the imbalance of lipid peroxidation and antioxidant activity in placenta is involved in the pathophysiology of preeclampsia. Increased TNF-alpha in the umbilical venous plasma showed inflammatory reaction in the placenta would be one of the cause of preclampsia. An antioxidant vitamin, ascorbic acid, may act an important antioxidant factor in preeclampsia.

키워드

자간전증;제대정맥혈장;interleukin-6;tumor necrosis factor-α;항산화제
preeclampsia;umbilical venous plasma;Interleukin-6;tumor necrosis factor-α;antioxidant
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