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Prenatally diagnosed agenesis of corpus callosum
±è±¤ÁØ ( Kim Gwang-Jun ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌÀº½Ç ( Lee Eun-Sil ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌÀºÁÖ ( Lee Eun-Ju ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
Çѽ¼ö ( Han Seung-Su ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌ»óÈÆ ( Lee Sang-Hoon ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èµ¿È£ ( Kim Dong-Ho ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌÁ¤ÁÖ ( Lee Jung-Ju ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ ¼Ò¾Æ°úÇб³½Ç
À±½Å¿ø ( Yun Sin-Weon ) - Áß¾Ó´ëÇб³ Àǰú´ëÇÐ ¼Ò¾Æ°úÇб³½Ç
Abstract
¸ñÀû: »êÀü ÃÊÀ½ÆÄ°Ë»ç»ó Áø´ÜµÈ ³ú·®¹«Çü¼ºÁõ žÆÀÇ ÀÓ»óÀû Ư¡À» ¾Ë¾Æº¸°íÀÚÇÑ´Ù.
¿¬±¸ ¹æ¹ý: 1998³â 1¿ùºÎÅÍ 2007³â 12¿ù±îÁö 22¿¹ÀÇ ³ú·®¹«Çü¼ºÁõ žƸ¦ °æÇèÇÏ¿´À¸¸ç, ÃÊÀ½ÆÄ°Ë»ç°á°ú¿Í Àǹ«±â·ÏÀ» ÈÄÇâÀûÀ¸·Î Á¶»çÇÏ¿´´Ù. °æº¹½Ä ÃÊÀ½ÆÄ ŽÃËÀÚ¿Í °æÁú½Ä ŽÃËÀÚ¸¦ ÀÌ¿ëÇÏ¿´À¸¸ç, »ïÂ÷¿ø ´Ù¸é½Ä (3D multi-slice technique) ¹æ¹ý°ú »öµµÇ÷¯¸¦ ºÎ°¡ÀûÀ¸·Î ÀÌ¿ëÇÏ¿´´Ù. »êÀüÁø´ÜÀº ÃÊÀ½ÆÄ·Î ³ú·®À» Á÷Á¢ È®ÀÎÇÔÀ¸·Î ÀÌ·ç¾îÁ³´Ù.
°á°ú: º»¿ø¿¡¼ ³ú·®¹«Çü¼º Áø´Ü½Ã Æò±Õ ÀçÅ¿¬·ÉÀº 26ÁÖ (19ÁÖ-34ÁÖ)¿´´Ù. °¡Àå ÈçÇÑ ÃÊÀ½ÆÄ ¼Ò°ßÀº ³ú½ÇÈ®Àå (19¿¹) À̾ú°í, Åõ¸í»çÀ̸·°ø°£ÀÌ ¾ø´Â ¼Ò°ßÀÌ ±× ´ÙÀ½À¸·Î 18¿¹¿¡¼ °üÂûµÇ¾ú´Ù. Á¦»ï³ú½ÇÀÌ È®ÀåµÇ¸é¼ »óÇâ º¯À§µÈ ¼Ò°ßÀÌ 15¿¹¿¡¼ ÀÖ¾ú´Ù. ¹Ý¼öÀÇ ³ú·®¹«Çü¼ºÁõ žƴ »êÀü ÃÊÀ½ÆÄ°Ë»ç¿¡¼ ´Üµ¶º´º¯À¸·Î ¿©°ÜÁ³À¸³ª Ãâ»ý ÈÄ ÇÑ ¸íÀº ½É±âÇüÀÌ ¹ß°ßµÇ¾ú°í, ¶Ç ´Ù¸¥ Çϳª´Â Aicardi ÁõÈıºÀ̾ú´Ù. ¿°»öüºÐ¼®Àº 14¿¹¿¡¼ ÇàÇØÁ³À¸¸ç, 1¿¹ÀÇ ¿¡µå¿öµå ÁõÈıºÀÌ ¹ß°ßµÇ¾ú´Ù. Ãâ»ê ÈÄ ÃÖÁ¾ È®ÀÎ °úÁ¤Àº 9¿¹¿¡¼ °¡´ÉÇÏ¿´À¸¸ç, 4¸íÀÇ »ýÁ¸ Ãâ»ý¾Æ´Â MRI¿¡ ÀÇÇØ¼, 5¸íÀÇ »ç»ê¾Æ´Â ºÎ°Ë¿¡ ÀÇÇØ¼ È®ÀεǾú´Ù. ÀÓ½ÅÁ¾°áÀº 9¿¹¿¡¼ ÀÖ¾ú°í, »êÀü Áø´Ü ÈÄ °æ°ú°üÂûÀ» ÇÒ ¼ö ¾ø¾ú´ø °æ¿ì°¡ 9¿¹¿´´Ù.
°á·Ð: ³ú·®¹«Çü¼ºÀÇ »êÀüÁø´ÜÀº ÃÊÀ½ÆÄ¿¡ ÀÇÇØ °¡´ÉÇÏ´Ù. ÇÏÁö¸¸ ¿¹ÈÄ¿Í Á÷Á¢ÀûÀÎ ¿¬°ü¼ºÀÌ ÀÖ´Â º¹ÇÕ±âÇü°ú ´Üµ¶¹ß»ýÀ» ±¸ºÐÇÏ´Â °ÍÀº ½±Áö¾ÊÀ¸¸ç, µû¶ó¼ »êÀü ÃÊÀ½ÆÄ»ó ´Üµ¶¹ß»ý ³ú·®¹«Çü¼ºÀ¸·Î Áø´ÜµÇ¾îµµ »ó´ãÀº Á¶½É½º·´°Ô ÀÌ·ç¾îÁ®¾ßÇÑ´Ù.
Objective: To report the clinical characteristics of the fetuses with agenesis of corpus callosum (ACC) diagnosed by prenatal ultrasonography.
Methods: Between 1998 and 2007, total twenty-two cases of ACC were identified. All cases were diagnosed by the direct evaluation of the corpus callosum using the ultrasonograpy with or without 3D multi-slice technique and color Doppler. Postnatal work-up was done by MRI or autopsy.
Results: The median gestational week was 26 weeks (19 to 34 weeks). The most common abnormal ultrasonographic finding was ventriculomegaly, shown in 19 (86.3%) of 22 cases. Absent cavum septum pellucidum and dilated upward displacement of third ventricle were also shown in 18 (81.8%) and 15 (68.2%) of 22 cases, respectively. Postnatal work-up performed in 9 cases (4 live-born babies and 5 still births) additionally confirmed the associated anomalies in three cases including a heart defect, an Aicardi syndrome, and trisomy 18.
Conslusion: The analysis of 22 cases presented in this report provides the precise materials to understand ACC. Targeted ultrasonographic evaluation may be helpful for prenatal diagnosis of ACC but has the limitation in differentiation of an isolated ACC from complex defect. To solve this limitation, therefore, the meticulous prenatal work-up and counseling would be needed.
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Agenesis of corpus callosum;Prenatal diagnosis
KMID :
0358420090520121239
DOI :
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