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What is fetal programming?: a lifetime health is under the control of in utero health

대한산부인과학회지 2017년 60권 6호 p.506 ~ 519
 ( Kwon Eun-Jin ) - Ewha Womans University School of Medicine Department of Obstetrics and Gynecology

 ( Kim Young-Ju ) - Ewha Womans University School of Medicine Department of Obstetrics and Gynecology

Abstract


The “Barker hypothesis” postulates that a number of organ structures and associated functions undergo programming during embryonic and fetal life, which determines the set point of physiological and metabolic responses that carry into adulthood. Hence, any stimulus or insult at a critical period of embryonic and fetal development can result in developmental adaptations that produce permanent structural, physiological and metabolic changes, thereby predisposing an individual to cardiovascular, metabolic and endocrine disease in adult life. This article will provide evidence linking these diseases to fetal undernutrition and an overview of previous studies in this area as well as current advances in understanding the mechanism and the role of the placenta in fetal programming.

키워드

Fetal development; Fetal nutrition disorders; Chronic disease
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